Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
Abstract
Background: null Epithelial barrier function is impaired in Crohn’s disease. null null Aim: null To define the underlying cellular mechanisms with special attention to tight junctions. null null Methods: null Biopsy specimens from the sigmoid colon of patients with mild to moderately active or inactive Crohn’s disease were studied in Ussing chambers, and barrier function was determined by impedance analysis and conductance scanning. Tight...
Paper Details
Title
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
Published Date
Jan 1, 2007
Journal
Volume
56
Issue
1
Pages
61 - 72
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