Original paper
Flap Endonuclease 1
Abstract
First discovered as a structure-specific endonuclease that evolved to cut at the base of single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component of cellular DNA metabolism. Substrate specificity allows FEN1 to process intermediates of Okazaki fragment maturation, long-patch base excision repair, telomere maintenance, and stalled replication fork rescue. For Okazaki fragments, the RNA primer is displaced into a 5'...
Paper Details
Title
Flap Endonuclease 1
Published Date
Jun 2, 2013
Volume
82
Issue
1
Pages
119 - 138
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Notes
History