De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia
Abstract
To evaluate evidence for de novo etiologies in schizophrenia, we sequenced at high coverage the exomes of families recruited from two populations with distinct demographic structures and history. We sequenced a total of 795 exomes from 231 parent-proband trios enriched for sporadic schizophrenia cases, as well as 34 unaffected trios. We observed in cases an excess of de novo nonsynonymous single-nucleotide variants as well as a higher prevalence...
Paper Details
Title
De novo gene mutations highlight patterns of genetic and neural complexity in schizophrenia
Published Date
Dec 1, 2012
Journal
Volume
44
Issue
12
Pages
1365 - 1369
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History