The Effect of ACACB cis-Variants on Gene Expression and Metabolic Traits
Abstract
Acetyl Coenzyme A carboxylase β (ACACB) is the rate-limiting enzyme in fatty acid oxidation, and continuous fatty acid oxidation in Acacb knock-out mice increases insulin sensitivity. Systematic human studies have not been performed to evaluate whether ACACB variants regulate gene expression and insulin sensitivity in skeletal muscle and adipose tissues. We sought to determine whether ACACB transcribed variants were associated with ACACB gene...
Paper Details
Title
The Effect of ACACB cis-Variants on Gene Expression and Metabolic Traits
Published Date
Aug 26, 2011
Journal
Volume
6
Issue
8
Pages
e23860 - e23860
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