DNA requirements for assembly and stability of HIV-1 intasomes
Abstract
Integration of viral DNA into the host genome is an essential step in retroviral replication that is mediated by a stable nucleoprotein complex comprising a tetramer of integrase bridging the two ends of the viral DNA in a stable synaptic complex (SSC) or intasome. Assembly of HIV-1 intasomes requires several hundred base pairs of nonspecific internal DNA in addition to the terminal viral DNA sequence that is protected in footprinting...
Paper Details
Title
DNA requirements for assembly and stability of HIV-1 intasomes
Published Date
Jan 18, 2012
Journal
Volume
21
Issue
2
Pages
249 - 257
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