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Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL.

Published on Mar 1, 2008in Magnetic Resonance in Medicine3.86
· DOI :10.1002/mrm.21561
Hyeonjin Kim5
Estimated H-index: 5
(Yale University),
Sara E. Taksali19
Estimated H-index: 19
(Yale University)
+ 6 AuthorsR. Todd Constable81
Estimated H-index: 81
(Yale University)
Cite
Abstract
Hepatic fat fraction (HFF) was measured in 28 lean/obese humans by single-voxel proton spectroscopy (MRS), a two-point Dixon (2PD) and a three-point iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL) method (3PI). For the lean, obese and total subject groups, the range of HFF measured by MRS was 0.3–3.5% (1.1±1.4%), 0.3–41.5% (11.7±12.1), and 0.3–41.5% (10.1±11.6%), respectively For the same groups, the HFF measured by 2PD was −6.3–2.2% (−2.0±3.7%), −2.4–42.9% (12.9±13.8%), and −6.3–42.9% (10.5±13.7%), respectively, and for 3PI they were 7.9–12.8% (10.1±2.0%), 11.1–49.3% (22.0±12.2%), and 7.9–49.3% (20.0±11.8%), respectively. The HFF measured by MRS was highly correlated with those measured by 2PD (r=0.954, p<0.001) and 3PI (r=0.973, p<0.001). With the MRS data as a reference, the percentages of correct diagnosis of fatty liver with the MRI methods ranged 75–93% for 2PI and 79–89% for 3PI. Our study demonstrates that the apparent HFF measured by the MRI methods can significantly vary depending on the choice of water-fat separation methods and sequences. Such variability may limit the clinical application of the MRI methods, particularly when a diagnosis of early fatty liver needs to be performed. Therefore, protocol-specific establishment of cutoffs for liver fat content may be necessary.
  • References (38)
  • Citations (155)
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References38
Newest
Published on Aug 1, 2007in Magnetic Resonance in Medicine3.86
Hyeonjin Kim5
Estimated H-index: 5
(Yale University),
Alexander B. Pinus2
Estimated H-index: 2
(Yale University)
+ 2 AuthorsR. Todd Constable81
Estimated H-index: 81
(Yale University)
Chemical shift-based multipoint water-fat separation methods have been applied in balanced steady-state free precession (bSSFP) sequences because of the high signal-to-noise-ratio (SNR) attainable. In this approach the echo formation is approximated to occur concurrently for both water and fat at an echo time (TE) equal to half the repetition time (TR/2 approximation). However, the degree to which the imaging conditions underlying the TR/2 approximation are satisfied can significantly vary in vi...
Published on Jun 1, 2007in European Journal of Radiology2.95
Sebastian Schuchmann27
Estimated H-index: 27
,
C. Weigel7
Estimated H-index: 7
+ 5 AuthorsNorbert Hosten36
Estimated H-index: 36
Abstract Introduction Even mild hepatic steatosis in a split liver donor may cause general liver failure and death in the donor. So far, CT density measurements or percutaneous biopsy is used to determine the presence of hepatic steatosis. Magnetic resonance imaging (MRI) may be an elegant method of non-invasive and non-radiation quantification of hepatic fat content. Methods Fast gradient echo (GRE) technique was used to discriminate between fat and water spins. Echo time (TE) was adjusted for ...
Published on Feb 1, 2007in Radiology7.61
Antonio C. Westphalen28
Estimated H-index: 28
(UCSF: University of California, San Francisco),
Aliya Qayyum34
Estimated H-index: 34
+ 5 AuthorsFergus V. Coakley47
Estimated H-index: 47
(UCSF: University of California, San Francisco)
Purpose: To retrospectively determine the effect of liver iron deposition on the evaluation of liver fat by using opposed-phase magnetic resonance (MR) imaging. Materials and Methods: Committee on Human Research approval was obtained, and compliance with HIPAA regulations was observed. Patient consent was waived by the committee. Thirty-eight patients with cirrhosis (30 men, eight women; mean age, 58 years; range, 34–76 years) who underwent abdominal MR imaging and had contemporaneous liver biop...
Published on Dec 1, 2006in Journal of Hepatology18.95
Paul E. Sijens27
Estimated H-index: 27
(UMCG: University Medical Center Groningen),
Gerrit Smit29
Estimated H-index: 29
(UMCG: University Medical Center Groningen)
+ 2 AuthorsMatthijs Oudkerk61
Estimated H-index: 61
(UMCG: University Medical Center Groningen)
Background/Aims Phosphorylase-b deficient patients suffer from glycogen storage disease (GSD IXa) leading to liver enlargement which usually resolves during puberty and adolescence. This pathology has not yet been documented by 1 H MR spectroscopy (MRS) investigation. Methods MRS of eight GSD IXa patients was performed in this study to assess whether or not liver fat content is elevated in GSD IXa and decreases with aging. An improvement in our MRS method compared with previous liver fat MRS stu...
Kitt Falk Petersen64
Estimated H-index: 64
,
Sylvie Dufour56
Estimated H-index: 56
+ 5 AuthorsGerald I. Shulman142
Estimated H-index: 142
Type 2 diabetes mellitus (T2DM) is strongly associated with obesity in most, but not all, ethnic groups, suggesting important ethnic differences in disease susceptibility. Although it is clear that insulin resistance plays a major role in the pathogenesis of T2DM and that insulin resistance is strongly associated with increases in hepatic (HTG) and/or intramyocellular lipid content, little is known about the prevalence of insulin resistance and potential differences in intracellular lipid distri...
Published on Nov 1, 2006in The Journal of Clinical Endocrinology and Metabolism5.61
Tania S. Burgert14
Estimated H-index: 14
,
Sara E. Taksali19
Estimated H-index: 19
+ 9 AuthorsMary Savoye24
Estimated H-index: 24
Findings: Elevated ALT (35 U/liter) was found in 14% of adolescents, with a predominance of male gender and white/Hispanic race/ ethnicity. After adjusting for potential confounders, rising ALT was associated with reduced insulin sensitivity and glucose tolerance as well as rising free fatty acids and triglycerides. Worsening of glucose and lipid metabolism was already evident as ALT levels rose into the upper half of the normal range (18–35 U/liter). When hepatic fat fraction was assessed using...
Published on Nov 1, 2006in Diabetes, Obesity and Metabolism6.13
Dick C. Chan37
Estimated H-index: 37
(UWA: University of Western Australia),
Watts G.F.80
Estimated H-index: 80
(UWA: University of Western Australia)
+ 3 AuthorsP.H.R. Barrett17
Estimated H-index: 17
(UWA: University of Western Australia)
Aim: We compared the use of magnetic resonance imaging (MRI) as a test for liver fat content (LFAT) with proton magnetic resonance spectroscopy (MRS) and investigated its relationship with body fat distribution, insulin sensitivity, plasma lipids and lipoproteins. Methods: LFAT was quantified by MRI and MRS in 17 free-living, healthy men with a wide range of body mass indexes. Fasting adiponectin was measured by immunoassay and insulin resistance by homeostasis assessment (HOMA) score. Intraperi...
Published on Sep 1, 2006in British Journal of Radiology1.94
Kieren G. Hollingsworth31
Estimated H-index: 31
(University of Cambridge),
M Z Abubacker1
Estimated H-index: 1
(University of Cambridge)
+ 2 AuthorsDavid J. Lomas31
Estimated H-index: 31
(University of Cambridge)
Low carbohydrate diets are currently fashionable for inducing weight loss, but the metabolic effects at organ level are not well understood, especially the effect on liver fat storage. Such studies require serial hepatic fat measurements, for which liver biopsy is impractical. In 10 healthy volunteers we demonstrate the use of rapid (total 2 min acquisition time, 10 min magnet room time), non-invasive, quantitative MRI to serially measure hepatic fat changes induced by following a low carbohydra...
Published on Jul 1, 2006in Acta Paediatrica2.27
Giorgio Radetti2
Estimated H-index: 2
,
Wolfgang Kleon2
Estimated H-index: 2
+ 1 AuthorsKlaus Pittschieler5
Estimated H-index: 5
Aim: To investigate the prevalence of non-alcoholic fatty liver disease (NAFLD) in a group of obese children (BMI> 97th %) and to establish correlations between the severity of hepatic fatty infiltration, auxological findings and parameters of insulin resistance. Methods: 44 obese children, aged 6–16 years, with a BMI above the 97th centile were selected for analysis. Hepatic fat content was assessed by phase contrast MRI. Demographic data included weight, height, body mass index, body fat mass ...
Published on Apr 1, 2006in Magnetic Resonance in Medicine3.86
Jürgen Machann50
Estimated H-index: 50
(University of Tübingen),
Claus Thamer36
Estimated H-index: 36
(University of Tübingen)
+ 5 AuthorsFritz Schick61
Estimated H-index: 61
(University of Tübingen)
Fat-selective MRI was applied to assess the amount and spatial distribution of hepatic lipids (HL) in healthy subjects. The results were compared with those obtained by localized 1H-MR spectroscopy (MRS). Ninety subjects (23–63 years old) underwent single-slice fat-selective MRI with spatial-spectral excitation and volume-localized spectroscopy at 1.5 T. HLs were analyzed in ventral and dorsal regions of interest (ROIs) of the liver in fat-selective images. Spectra were evaluated using the integ...
Cited By155
Newest
Published on Aug 28, 2019
Min Ki Shin , Ji Soo Song3
Estimated H-index: 3
+ 3 AuthorsWoo Sung Moon29
Estimated H-index: 29
Liver fibrosis staging is of great clinical importance because it is used to assess the severity of the underlying chronic liver disease. Among various imaging-based methods, apparent diffusion coefficient (ADC) measurement using diffusion-weighted imaging (DWI) has the potential to be used as an imaging biomarker for liver fibrosis assessment. In this study, we investigated the usefulness of liver ADC normalization using the spleen as a reference organ in liver fibrosis staging with 66 patients...
Published on 2019in bioRxiv
Ahmad A Alhulail (Purdue University), Debra A Patterson (Purdue University)+ 5 AuthorsUzay E. Emir18
Estimated H-index: 18
(Purdue University)
Purpose: To provide a rapid, non-invasive fat quantification technique capable of producing separate lipid component maps. Methods: The calf muscles in 5 healthy adolescents (age 12-16 years; BMI = 20 ± 3 Kg/m2) were scanned by two different fat fraction (FF) quantification methods. A high-resolution, density-weighted concentric ring trajectory (DW-CRT) metabolite cycling (MC) magnetic resonance spectroscopic imaging (MRSI) technique was implemented to collect data with 0.25 mL resolution within...
Published on Jul 17, 2019in Hepatology Research3.44
Hiroyuki Igarashi1
Estimated H-index: 1
(Toho University),
Fumika Shigiyama3
Estimated H-index: 3
(Toho University)
+ 5 AuthorsNaoki Kumashiro4
Estimated H-index: 4
(Toho University)
Published on 2019in International Journal of Legal Medicine2.09
Yohsuke Makino7
Estimated H-index: 7
(UTokyo: University of Tokyo),
Masatoshi Kojima (Chiba University)+ 7 AuthorsNaoki Saito2
Estimated H-index: 2
(Chiba University)
Objective To elucidate postmortem computed tomography (PMCT) and postmortem magnetic resonance (PMMR) imaging findings suggesting massive fat embolism.
Published on Apr 3, 2019in British Journal of Biomedical Science2.37
Ali Al-Radaideh9
Estimated H-index: 9
(HU: Hashemite University),
Reema F. Tayyem15
Estimated H-index: 15
(UJ: University of Jordan)
+ 5 AuthorsNawal Hijjawi15
Estimated H-index: 15
(HU: Hashemite University)
ABSTRACTBackground and aim: This relatively comprehensive and multi-parametric study was conducted to investigate an association between hepatic fat percentage (HFP) values measured using high-field magnetic resonance imaging (MRI), anthropometric and biochemical measurements in healthy adults.Methods: Abdominal MRI, anthropometric and biochemical measurements were determined in 156 healthy subjects. HFP values were derived from the MRI, whilst routine lipids, leptin, resistin, IL6 and adiponect...
Published on Apr 1, 2019in Abdominal Radiology2.15
Ruo-Mi Guo8
Estimated H-index: 8
(SYSU: Sun Yat-sen University),
Ru-zhen Zhao (SYSU: Sun Yat-sen University)+ 5 AuthorsQingling Li1
Estimated H-index: 1
(SYSU: Sun Yat-sen University)
Purpose The objective of this study was to quantitatively assess fat deposition in the testis and epididymis by measuring the fat/water signal ratios with mDIXON Quant and to investigate its correlation with age and ejaculation.
Published on Apr 1, 2019in International Journal of Rheumatic Diseases1.94
Bon San Koo1
Estimated H-index: 1
(Inje University),
Yoonah Song3
Estimated H-index: 3
(Hanyang University)
+ 2 AuthorsTae-Hwan Kim36
Estimated H-index: 36
(Hanyang University)
Published on Apr 1, 2019in International Journal of Obesity4.51
Giuseppina Rosaria Umano4
Estimated H-index: 4
(Yale University),
Veronika Shabanova9
Estimated H-index: 9
(Yale University)
+ 6 AuthorsSonia Caprio65
Estimated H-index: 65
(Yale University)
The relative proportion of visceral fat (VAT) to subcutaneous fat (SAT) has been described as a major determinant of insulin resistance (IR). Our study sought to evaluate the effect of body fat distribution on glucose metabolism and intrahepatic fat content over time in a multiethnic cohort of obese adolescents. We examined markers of glucose metabolism by oral glucose tolerance test, and body fat distribution by abdominal MRI at baseline and after 19.2 ± 11.4 months in a cohort of 151 obese ado...
Published on Jan 1, 2019in Hepatology Research3.44
Yoshio Sumida30
Estimated H-index: 30
(Aichi Medical University),
Yoshio Sumida4
Estimated H-index: 4
(Aichi Medical University)
+ 4 AuthorsTakeshi Osonoi15
Estimated H-index: 15
Published on Jan 1, 2019in Korean Journal of Radiology3.73
Sang Hyup Lee1
Estimated H-index: 1
(SNU: Seoul National University),
Hye Jin Yoo4
Estimated H-index: 4
(SNU: Seoul National University)
+ 3 AuthorsHee Dong Chae3
Estimated H-index: 3
(SNU: Seoul National University)