Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality

Volume: 54, Issue: 3, Pages: 622 - 635
Published: Mar 1, 2013
Abstract
Human mesenchymal stem/stromal cells (hMSC) are increasingly used in advanced cellular therapies. The clinical use of hMSCs demands sequential cell expansions. As it is well established that membrane glycerophospholipids (GPL) provide precursors for signaling lipids that modulate cellular functions, we studied the effect of the donor's age and cell doublings on the GPL profile of human bone marrow MSC (hBMSC). The hBMSCs, which were harvested...
Paper Details
Title
Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality
Published Date
Mar 1, 2013
Volume
54
Issue
3
Pages
622 - 635
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