Lipotoxicity in Diabetic Nephropathy: The Potential Role of Fatty Acid Oxidation
Volume: 5, Issue: 12, Pages: 2373 - 2379
Published: Dec 1, 2010
Abstract
Cellular toxicity mediated by lipids (lipotoxicity) has been implicated in the pathophysiology of metabolic syndrome and diabetes mellitus. Genetic analyses now implicate lipotoxicity in susceptibility to type 2 diabetes mellitus-associated nephropathy (T2DN), a pathway that had previously been unexplored. A genome-wide association study in Japanese patients identified a single nucleotide polymorphism in the acetyl-CoA carboxylase β (ACACB) gene...
Paper Details
Title
Lipotoxicity in Diabetic Nephropathy: The Potential Role of Fatty Acid Oxidation
Published Date
Dec 1, 2010
Volume
5
Issue
12
Pages
2373 - 2379
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