Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells
Abstract
Over-expression of AURKC has been detected in human colorectal cancers, thyroid carcinoma and several cancer cell lines. However, the regulation and clinical implications of over-expressed AURKC in cancer cells are unclear. Here we show that elevated AURKC increases the proliferation, transformation and migration of cancer cells. Importantly, the kinase activity of AURKC is required for these tumour-associated properties. Analysis of human...
Paper Details
Title
Aberrantly expressed AURKC enhances the transformation and tumourigenicity of epithelial cells
Published Date
Jun 27, 2011
Journal
Volume
225
Issue
2
Pages
243 - 254
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