Identification of disulfide bond isomerase substrates reveals bacterial virulence factors

Volume: 94, Issue: 4, Pages: 926 - 944
Published: Oct 20, 2014
Abstract
Bacterial pathogens are exposed to toxic molecules inside the host and require efficient systems to form and maintain correct disulfide bonds for protein stability and function. The intracellular pathogen Francisella tularensis encodes a disulfide bond formation protein ortholog, DsbA, which previously was reported to be required for infection of macrophages and mice. However, the molecular mechanisms by which F. tularensis DsbA contributes to...
Paper Details
Title
Identification of disulfide bond isomerase substrates reveals bacterial virulence factors
Published Date
Oct 20, 2014
Volume
94
Issue
4
Pages
926 - 944
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