Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.

Volume: 7, Issue: 3, Pages: 236 - 245
Published: Jul 1, 2005
Abstract
U87MG human glioma cells in cultures expressed metabotropic glutamate (mGlu) receptors mGlu2 and mGlu3. Addition of the mGlu2/3 receptor antagonist LY341495 to the cultures reduced cell growth, expression of cyclin D1/2, and activation of the MAP kinase and phosphatidylinositol-3-kinase pathways. This is in line with the evidence that activation of mGlu2/3 receptors sustains glioma cell proliferation. U87MG cells were either implanted under the...
Paper Details
Title
Pharmacological blockade of group II metabotropic glutamate receptors reduces the growth of glioma cells in vivo.
Published Date
Jul 1, 2005
Volume
7
Issue
3
Pages
236 - 245
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