Gordura visceral e síndrome metabólica: mais que uma simples associação

Published on Apr 1, 2006in Arquivos Brasileiros De Endocrinologia E Metabologia
· DOI :10.1590/S0004-27302006000200009
Fernando Flexa Ribeiro Filho8
Estimated H-index: 8
(Federal University of São Paulo),
Lydia Sebba Souza Mariosa2
Estimated H-index: 2
(Federal University of São Paulo)
+ 1 AuthorsMaria Teresa Zanella20
Estimated H-index: 20
(Federal University of São Paulo)
Abstract
Metabolic syndrome (MS) is seen nowadays as a worldwide epidemic event associated with high cardiovascular morbi-mortality and high socioeconomic cost. The ponderal gain is an independent predictor for the development of MS, although not all obese individuals present it. On the other hand, some populations with low obesity prevalence present high prevalence of MS and cardiovascular mortality. The distribution of corporal fat is relevant and visceral fat (VF), specifically, seems to be the link between adipose tissue and insulin resistance (IR), a mean feature of MS. Adipose tissue is now considered a complex organ with multiple functions. VF presents metabolic properties, which are different from the gluteo-femoral subcutaneous fat and related to IR. Several studies show the narrow relationship of abdominal adiposity with the glucose tolerance, hyperinsulinemia, hypertriglyceridemia and arterial hypertension. More than a simple association, recently it is thought that the VF plays a central part in the physiopathology of MS. Consequently, the quantification of VF plays an important role to identify individuals with larger risk for development of MS, who should be chosen for early interventions in the attempt of reducing the impact of metabolic abnormalities on cardiovascular mortality. This article discusses particularities of the central distribution of fat in MS context, possible physiopathogenic mechanisms related to the VF and available methods for the evaluation of abdominal adiposity.
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References79
Published on Jun 1, 2000in Canadian Journal of Cardiology 4.52
Timar O1
Estimated H-index: 1
,
Sestier F1
Estimated H-index: 1
,
Levy E1
Estimated H-index: 1
157 Citations
Published on Apr 1, 1993in International Journal of Obesity 5.16
Fabio Armellini19
Estimated H-index: 19
,
Mauro Zamboni45
Estimated H-index: 45
+ 4 AuthorsOttavio Bosello37
Estimated H-index: 37
Computerized tomography, a method of proven reliability for direct measurement of both total and visceral body fat, is not widely usable and alternative means of assessing body fat are required. Several anthropometric parameters, including ultrasound measurements of intra-abdominal and subcutaneous fat, were considered in 119 females (age 15-72 years, body mass index 24-51 kg/m 2 ). Computerized tomography was also performed for total and visceral fat areas at the L4-L5 level. Reliability of eac...
138 Citations
Published on Jul 1, 1996in International Journal of Obesity 5.16
M. J. Williams7
Estimated H-index: 7
,
Gary R. Hunter59
Estimated H-index: 59
+ 4 AuthorsTamilane E. Blaudeau7
Estimated H-index: 7
Intra-abdominal adipose tissue (IAF) seems to be the primary fat depot putting individuals at risk for cardiovascular disease (CVD). The purpose of this study was to determine IAF cut-points for identifying CVD risk in pre- and post-menopausal women. Age ranged from 18 to 77 y and percentage fat ranged from 9 to 48%. Computed tomography (CT), IAF, DEXA determined regional fat and blood lipid profiles were obtained on 220 Caucasian women. Student's t-tests were run to determine differences betwee...
101 Citations
Published on Apr 1, 1993in International Journal of Obesity 5.16
K. Van Der Kooy4
Estimated H-index: 4
,
J.C. Seidell79
Estimated H-index: 79
The measurement of fat distribution has become an important issue in obesity research. Numerous techniques have been developed to assess visceral fat because this fat seems to be most strongly associated with metabolic disorders. This review focuses on methods for the direct and indirect assessment of visceral fat ranging from multiple-scan computerized tomography to anthropometric measurements. The principles of techniques, their accuracy and reproducibility as well as aspects of costs and safe...
456 Citations
Published on Oct 1, 1990in International Journal of Obesity 5.16
S. Rössner1
Estimated H-index: 1
,
W. J. Bo1
Estimated H-index: 1
+ 5 AuthorsJ. R. Crouse1
Estimated H-index: 1
197 Citations
Published on Jan 1, 1992in International Journal of Obesity 5.16
J.C. Seidell79
Estimated H-index: 79
,
M. Cigolini1
Estimated H-index: 1
+ 3 AuthorsA. Cruz1
Estimated H-index: 1
79 Citations
R. V. Weber1
Estimated H-index: 1
(State University of New York System),
Marie-Claire Buckley1
Estimated H-index: 1
(State University of New York System)
+ 1 AuthorsJ. G. Kral1
Estimated H-index: 1
(State University of New York System)
The insulin resistance syndrome X is related to excess intra-abdominal adipose tissue. With lipectomy of >50% of subcutaneous adipose tissue (SQAT) in nonhibernating, adult female Syrian hamsters on high-fat (HF; 50 calorie%) diet and measurements of oral glucose tolerance, oral [14C]oleic acid disposal, serum triglycerides, serum leptin, liver fat, perirenal (PR) adipose tissue cellularity, and body composition, we studied the role of SQAT. Sham-operated (S) animals on HF or low-fat (LF; 12.5 c...
74 Citations Source Cite
Published on Apr 1, 1996in International Journal of Obesity 5.16
Per Björntorp78
Estimated H-index: 78
The regulation of adipose tissue distribution is an important problem in view of the close epidemiological and metabolic associations between centralized fat accumulation and disease. With visceral fat accumulation multiple endocrine perturbations are found, including elevated cortisol and androgens in women, as well as low growth hormone (GH) and, in men, testosterone (T) secretion. These abnormalities probably derive from a hypersensitive hypothalamo-pituitary-adrenal axis, with hyper-insuline...
574 Citations
Published on Dec 1, 2003in Obesity Research
Fernando F. Ribeiro-Filho10
Estimated H-index: 10
(Federal University of São Paulo),
Alessandra Nunes Faria10
Estimated H-index: 10
(Federal University of São Paulo)
+ 2 AuthorsSandra R.G. Ferreira18
Estimated H-index: 18
(Federal University of São Paulo)
Objective: To compare methods for the assessment of visceral fat with computed tomography (CT) and establish cutoffs to define visceral obesity based on such alternative methods. Research Methods and Procedures: One hundred women (50.4 ± 7.7 years; BMI 39.2 ± 5.4 kg/m2) underwent anthropometric evaluation, bioelectrical impedance, DXA, abdominal ultrasonography (US), and CT scan. Results: Waist circumference, waist-to-hip ratio (WHR), and US-determined visceral fat values showed the best correla...
207 Citations Source Cite
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Cited By110
Elaine Cristina Navarro2
Estimated H-index: 2
,
Mariana Miziara de Abreu2
Estimated H-index: 2
+ 3 AuthorsPaulo Camara Marques Pereira5
Estimated H-index: 5
(Sao Paulo State University)
Universidade Estadual Paulista Julio de Mesquita Filho, Departamento de Doencas Tropicais e Diagnostico Por Imagem, Faculdade de Medicina, Botucatu, Rubiao Junior s/no., Rubiao Junior, CEP 18618-900, SP, Brasil
1 Citations Source Cite
Published on Jun 14, 2013in Acta Scientiarum. Health Science
Kazuyuki Hashimoto (Universidade Estadual de Maringá), Mirian Hideco Takahashi (Universidade Estadual de Maringá)
This study evaluated the profile of patients submitted to gastroplasty in the University Hospital of Maringa during 2008-2009. Clinical charts were analyzed to obtain clinical and laboratory data of all patients with morbid obesity submitted to gastroplasty. During the study period, 28 surgeries were performed, 57% of the patients lived in Maringa, 82% female, 40 years average age, with mean body mass index (BMI) of 46.7kg m -2 . It was verified that 39% of the patients maintained an usual non-h...
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Published on Dec 1, 2010in Arquivos Brasileiros De Cardiologia 1.32
Anna Karla Carneiro Roriz6
Estimated H-index: 6
(Federal University of Bahia),
Adriana Lima Mello5
Estimated H-index: 5
(Federal University of Bahia)
+ 3 AuthorsLílian Ramos Sampaio10
Estimated H-index: 10
(Federal University of Bahia)
Mailing address: Anna Karla Carneiro Roriz • Avenida Araujo Pinho, 32 Canela 40110-150 Salvador, BA Brazil E-mail: karlaroriz@hotmail.com, annakarlaroriz@yahoo.com.br Manuscript received December 07, 2009; revised manuscript received June 18, 2010; accepted July 16, 2010. Abstract Background: Androgenic obesity is associated with a higher risk of metabolic disorders, thus favoring the occurrence of cardiovascular diseases and other morbidities.
5 Citations Source Cite
Published on Nov 1, 2009in Arquivos Brasileiros De Cardiologia 1.32
Márcia Bopp2
Estimated H-index: 2
,
Sandra Barbiero2
Estimated H-index: 2
Summary Background: Metabolic syndrome (MS) is considered a very important factor in the development of cardiovascular diseases (CVD). Objective: To assess the prevalence of metabolic syndrome (MS) in outpatients undergoing secondary prevention of coronary artery disease in the Institute of Cardiology, University Foundation of Cardiology – IC-UFC, as well as to detect excess weight through body mass index (BMI) and the prevalence of abdominal obesity in patients with cardiovascular disease (CVD)...
3 Citations Source Cite
Published on Jun 28, 2015in Motricidade
Alice Cristina Antonio dos Santos (Sao Paulo State University), Marcelo Papoti14
Estimated H-index: 14
+ 4 AuthorsJosé Carlos Silva Camargo Filho5
Estimated H-index: 5
(Sao Paulo State University)
The main aim of the present study was to analyse the effects induced by six weeks of swimming periodized training (SPT) on the aerobic capacity (AC) and body weight (BW), on rats fed with either normal or hypercaloric diets. Twenty-four Wistar rats (90 days old) were divided in two groups: Normocaloric (NG, n = 12) and Hypercaloric (HG, n = 12). The rats were fed with respective diets (NG or HG) for eight weeks and then underwent SPT for six weeks. Before (pre) and after (post) the SPT, the anim...
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Published on Jan 1, 2012in Nutricion Hospitalaria 0.84
F. Rodrigues de Oliveira Penaforte1
Estimated H-index: 1
(University of São Paulo),
C. Cremonezi Japur1
Estimated H-index: 1
(University of São Paulo)
+ 2 AuthorsP. García Chiarello1
Estimated H-index: 1
(University of São Paulo)
Introduction: Computerizd tomography (CT) is the gold standard for the evaluation of intra- (IAF) and total (TAF) abdominal fat; however, the high cost of the procedure and exposure to radiation limit its routine use. Objective: To develop equations that utilize anthropometric measures for the estimate of IAF and TAF in obese women with polycystic ovary syndrome (PCOS). Methods: The weight, height, BMI, and abdominal (AC), waist (WC), chest (CC), and neck (NC) circumferences of thirty obese wome...
1 Citations Source Cite
Published on Feb 1, 2011in Journal of Human Nutrition and Dietetics 2.68
Fernanda Rodrigues de Oliveira Penaforte3
Estimated H-index: 3
(University of São Paulo),
Camila Cremonezi Japur5
Estimated H-index: 5
(University of São Paulo)
+ 1 AuthorsPaula Garcia Chiarello12
Estimated H-index: 12
(University of São Paulo)
Background: Fat accumulation in the upper region of the body is common in polycystic ovary syndrome (PCOS) and is associated with metabolic complications. The present study aimed to assess the relationship between trunk circumference, metabolic indicators, and abdominal and visceral fat in obese PCOS women. Methods: The weight, fat mass, and subcutaneous arm fat (SAF) of 30 obese PCOS women and 15 healthy controls matched for age and body mass index were evaluated by bioelectrical impedance anal...
16 Citations Source Cite
Published on Jun 1, 2010in Arquivos Brasileiros De Cardiologia 1.32
Edmarlon Girotto1
Estimated H-index: 1
(Universidade Norte do Paraná),
Selma Maffei de Andrade22
Estimated H-index: 22
(Universidade Estadual de Londrina),
Marcos Aparecido Sarria Cabrera14
Estimated H-index: 14
(Universidade Estadual de Londrina)
FUNDAMENTO: A obesidade abdominal e importante fator de risco cardiovascular e, juntamente com as dislipidemias, a intolerância a glicose e a hipertensao arterial, compoe a sindrome metabolica. OBJETIVO: Verificar a prevalencia de obesidade abdominal e fatores associados em hipertensos. METODOS: Estudo transversal com hipertensos de 20 a 79 anos cadastrados em uma Unidade Saude da Familia do municipio de Londrina, Parana. A obesidade abdominal foi identificada por meio da relacao cintura-quadril...
33 Citations Source Cite
Ana Carolina Panveloski-Costa2
Estimated H-index: 2
(Sao Paulo State University),
Danilo Antônio Corrêa Pinto Júnior2
Estimated H-index: 2
(Sao Paulo State University)
+ 3 AuthorsPatricia Monteiro Seraphim11
Estimated H-index: 11
(Sao Paulo State University)
OBJECTIVE: To determine if resistive exercise protocol can modulate Tnf-α, SOCS3 and glucose transporter GLUT4 genes expression in skeletal muscle, and peripheral insulin sensitivity in obese rats induced by hyperlipidic diet. MATERIALS AND METHODS: Wistar obese rats induced by hyperlipidic diet were subjected a resistive exercise protocol as jump squat. Insulin sensitivity and mRNA content of Tnf-α, SOCS3 and GLUT4 were assayed and compared among the groups: obese sedentary (OS) and exercised (...
8 Citations Source Cite