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Gordura visceral e síndrome metabólica: mais que uma simples associação

Published on Apr 1, 2006in Arquivos Brasileiros De Endocrinologia E Metabologia
· DOI :10.1590/S0004-27302006000200009
Fernando Flexa Ribeiro Filho8
Estimated H-index: 8
(UNIFESP: Federal University of São Paulo),
Lydia Sebba Souza Mariosa2
Estimated H-index: 2
(UNIFESP: Federal University of São Paulo)
+ 1 AuthorsMaria Teresa Zanella19
Estimated H-index: 19
(UNIFESP: Federal University of São Paulo)
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Abstract
Metabolic syndrome (MS) is seen nowadays as a worldwide epidemic event associated with high cardiovascular morbi-mortality and high socioeconomic cost. The ponderal gain is an independent predictor for the development of MS, although not all obese individuals present it. On the other hand, some populations with low obesity prevalence present high prevalence of MS and cardiovascular mortality. The distribution of corporal fat is relevant and visceral fat (VF), specifically, seems to be the link between adipose tissue and insulin resistance (IR), a mean feature of MS. Adipose tissue is now considered a complex organ with multiple functions. VF presents metabolic properties, which are different from the gluteo-femoral subcutaneous fat and related to IR. Several studies show the narrow relationship of abdominal adiposity with the glucose tolerance, hyperinsulinemia, hypertriglyceridemia and arterial hypertension. More than a simple association, recently it is thought that the VF plays a central part in the physiopathology of MS. Consequently, the quantification of VF plays an important role to identify individuals with larger risk for development of MS, who should be chosen for early interventions in the attempt of reducing the impact of metabolic abnormalities on cardiovascular mortality. This article discusses particularities of the central distribution of fat in MS context, possible physiopathogenic mechanisms related to the VF and available methods for the evaluation of abdominal adiposity.
  • References (80)
  • Citations (112)
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References80
Newest
Published on Sep 1, 2005in Diabetes Care 15.27
Harold E. Lebovitz50
Estimated H-index: 50
,
Mary Ann Banerji16
Estimated H-index: 16
The relationship between obesity and insulin resistance, while well recognized for many years, has nonetheless been confusing since not all obese individuals have insulin resistance (1) and because insulin resistance occurs in individuals who have BMIs that are within the normal or mildly overweight categories (2). Early attempts to understand the relationships between obesity, type 2 diabetes, and cardiovascular disease focused on the waist-to-hip ratio as a means of distinguishing those indivi...
205 Citations Source Cite
Published on Sep 1, 2005in Diabetes Care 15.27
John M. Miles40
Estimated H-index: 40
,
Michael Dennis Jensen68
Estimated H-index: 68
It has been known for over half a century that accumulation of fat in the upper body is associated with metabolic complications of obesity. The mechanism responsible for this association is widely believed to be insulin resistance, which is frequently present in individuals with upper-body obesity (1) and is associated with increased cardiovascular risk (2). The upper-body obesity phenotype is accompanied by increased free fatty acid (FFA) flux and concentration, whereas individuals with predomi...
82 Citations Source Cite
Published on Aug 1, 2005in Current Medicinal Chemistry 3.89
Genovefa Kolovou26
Estimated H-index: 26
,
Katherine K. Anagnostopoulou20
Estimated H-index: 20
+ 2 AuthorsDennis V. Cokkinos47
Estimated H-index: 47
Several studies showed that after a fatty meal, plasma triglyceride (TG) levels are higher in patients with coronary heart disease. This abnormality may explain why some individuals develop atherosclerotic disease despite normal fasting lipid values. TG-rich lipoproteins are involved in atherosclerosis and thrombosis. TG, remnant-like particle (RLP) cholesterol (RLP-C) and RLP-TG increase after fat load and could contribute to atherothrombosis. Postprandial lipaemia is not a uniform abnormality....
103 Citations Source Cite
Published on Aug 1, 2005in Trends in Molecular Medicine 11.03
Jaswinder K. Sethi33
Estimated H-index: 33
(University of Cambridge),
Antonio Vidal-Puig73
Estimated H-index: 73
(University of Cambridge)
Human obesity-related diabetes and the accompanying metabolic disorders have been specifically linked to increased visceral adipose tissue mass. Understanding the differences in biology of the two human fat depots (visceral and subcutaneous) might hold the key to therapeutic strategies aimed at reducing obesity-induced insulin resistance and alleviating symptoms of the metabolic syndrome. Visfatin (pre-B-cell colony-enhancing factor, PBEF) is a novel adipokine that appears to be preferentially p...
178 Citations Source Cite
Published on Jun 1, 2005in Sleep Medicine Reviews 10.52
Alexandros N. Vgontzas61
Estimated H-index: 61
(PSU: Pennsylvania State University),
Edward O. Bixler70
Estimated H-index: 70
(PSU: Pennsylvania State University),
George P. Chrousos150
Estimated H-index: 150
(NIH: National Institutes of Health)
Summary Obstructive sleep apnea (OSA) is a prevalent disorder particularly among middle-aged, obese men, although its existence in women as well as in lean individuals is increasingly recognized. Despite the early recognition of the strong association between OSA and obesity, and OSA and cardiovascular problems, sleep apnea has been treated as a ‘local abnormality' of the respiratory track rather than as a ‘systemic illness.' In 1997, we first reported that the pro-inflammatory cytokines interle...
415 Citations Source Cite
Published on Apr 11, 2005in JAMA Internal Medicine 20.77
Bret H. Goodpaster80
Estimated H-index: 80
(University of Pittsburgh),
Shanthi Krishnaswami6
Estimated H-index: 6
(University of Pittsburgh)
+ 6 AuthorsA. B. Newman140
Estimated H-index: 140
(University of Pittsburgh)
Background:Themetabolicsyndromeisadisorderthat includes dyslipidemia, insulin resistance, and hypertension and is associated with an increased risk of diabetes andcardiovasculardisease.Wedeterminedwhetherpatterns of regional fat deposition are associated with metabolic syndrome in older adults. Methods: A cross-sectional study was performed that included a random, population-based, volunteer sample of Medicare-eligible adults within the general communities of Pittsburgh, Pa, and Memphis, Tenn. T...
444 Citations Source Cite
Morvarid Kabir14
Estimated H-index: 14
(SC: University of Southern California),
Karyn J. Catalano10
Estimated H-index: 10
(SC: University of Southern California)
+ 4 AuthorsRichard N. Bergman103
Estimated H-index: 103
(SC: University of Southern California)
The mechanism by which increased central adiposity causes hepatic insulin resistance is unclear. The “portal hypothesis” implicates increased lipolytic activity in the visceral fat and therefore increased delivery of free fatty acids (FFA) to the liver, ultimately leading to liver insulin resistance. To test the portal hypothesis at the transcriptional level, we studied expression of several genes involved in glucose and lipid metabolism in the fat-fed dog model with visceral adiposity vs. contr...
236 Citations Source Cite
Published on Jan 1, 2005in Acta Physiologica Scandinavica
Francesco Giorgino44
Estimated H-index: 44
,
Luigi Laviola31
Estimated H-index: 31
,
Jan W. Eriksson34
Estimated H-index: 34
(Umeå University)
Adipose tissue is now recognized to have a multitude of functions that are of importance in the regulation of energy balance and substrate metabolism. Different hormones, in particular insulin and catecholamines, govern the storage and utilization of energy in the triglyceride depots. In addition, adipocytes produce several different substances with endocrine or paracrine functions, which regulate the overall energetic homeostasis. With excess energy storage, obesity develops, leading to increas...
187 Citations Source Cite
Helen Hermana Miranda Hermsdorff20
Estimated H-index: 20
(UFV: Universidade Federal de Viçosa),
Josefina Bressan Resende Monteiro9
Estimated H-index: 9
(UFV: Universidade Federal de Viçosa)
O tecido adiposo e um orgao dinâmico que secreta varios fatores, denominados adipocinas. Eles estao relacionados, direta ou indiretamente, em processos que contribuem na aterosclerose, hipertensao arterial, resistencia insulinica e diabetes tipo 2, dislipidemias, ou seja, representam o elo entre adiposidade, sindrome metabolica e doencas cardiovasculares. Na obesidade, os depositos de gordura corporal estao aumentados, apresentando consequente elevacao na expressao e secrecao das adipocinas, pro...
70 Citations Source Cite
Cited By112
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Published on Apr 1, 2018in Jornal De Pediatria 1.69
Rommel Larcher Rachid Novais (UFSJ: Universidade Federal de São João del-Rei), Ana Carolina Corrêa Café (UFSJ: Universidade Federal de São João del-Rei)+ 6 AuthorsJoel Alves Lamounier4
Estimated H-index: 4
(UFSJ: Universidade Federal de São João del-Rei)
Abstract Objective To associate intra-abdominal fat thickness measured by ultrasonography to the factors related to metabolic syndrome and to determine cutoff points of intra-abdominal fat measurement associated with a greater chance of metabolic syndrome in adolescents. Methods This was a cross-sectional study, with 423 adolescents from public schools. Intra-abdominal fat was measured by ultrasonography. Anthropometric data were collected, and biochemical analyses were performed. Results Intra-...
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Published on Apr 22, 2019in bioRxiv
Queiroz Machado (Federal Fluminense University), Cristina Pereira-Silva (Federal Fluminense University)+ 1 AuthorsFernandes-Santos
Objectives: To investigate the early cardiometabolic abnormalities along with WAT and BAT remodeling in short-term fructose feeding mice model. Methods: Mice (n=10-11/group) were fed for four weeks with control diet (AIN93-M) or experimental diets rich in glucose or fructose. We investigated body weight, body adiposity, blood glucose, lipid and hepatic parameters, and white (WAT) and brown adipose tissue (BAT) histopathology. Results: Fructose feeding promoted neither weight gain nor hypertrophy...
1 Citations Source Cite
Published on Feb 28, 2019in Oxidative Medicine and Cellular Longevity 4.87
Cecília Maria Passos Vázquez1
Estimated H-index: 1
(UFS: Universidade Federal de Sergipe),
Jamille Oliveira Costa2
Estimated H-index: 2
(UFS: Universidade Federal de Sergipe)
+ 8 AuthorsTatiana Rodrigues de Moura7
Estimated H-index: 7
(UFS: Universidade Federal de Sergipe)
Oxidative and inflammatory substances play an important role in the genesis of processes related to cardiometabolic risk. High levels of oxidized low-density lipoprotein (Ox-LDL) and of triggering receptor-expressed myeloid cells (TREM-1) are associated with cardiovascular and inflammatory diseases. In this study, we evaluate the association of the plasma concentrations of Ox-LDL and serum levels of circulating TREM-1 (sTREM-1) with the components of cardiometabolic risk (CMR) and other associat...
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Published on Sep 29, 2018in Archives of Physiology and Biochemistry 2.11
Daniella Regina Barrionuevo da Silva Novi2
Estimated H-index: 2
,
Camila B. Vidigal1
Estimated H-index: 1
+ 7 AuthorsGraziela S. Ceravolo10
Estimated H-index: 10
AbstractObjective: The aim was to evaluate if maternal treatment with metformin (MET) during pregnancy and lactation could be safe for metabolic and cardiovascular parameters of adult male and female offspring.Materials and methods: Wistar female rats were treated with MET (293 mg/kg/d) or tap water, by gavage during gestation (METG or CTRG) or gestation and lactation (METGL or CTRGL).Results: At 75 days of life, male and female MET offspring presented similar blood pressure when compared with t...
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Published on Jul 27, 2018in Nutrients 4.17
Jordana Herzog Siqueira1
Estimated H-index: 1
,
José Geraldo Mill32
Estimated H-index: 32
+ 4 AuthorsMariadel C. B. Molina16
Estimated H-index: 16
The secular trend of hyperuricemia coincides with the substantial increase in the consumption of sugar-sweetened beverages. Our aim was to evaluate the association between the consumption of soft drinks, dietary fructose and unsweetened, non-processed fruit juices with hyperuricemia in a cross-sectional analysis of baseline data (2008–2010; n = 7173) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The explanatory variables were the consumption of soft drinks, fruit juice, and ...
3 Citations Source Cite
Published on Dec 1, 2017in Nutrire
Barbara Perez Vogt5
Estimated H-index: 5
,
Jacqueline Socorro Costa Teixeira Caramori15
Estimated H-index: 15
(UNESP: Sao Paulo State University)
Evaluation of body fat and its distribution are important because they can predict several risk factors, mainly cardiovascular risk. Imaging techniques have high precision and accuracy for body fat measurement. However, trained personnel are required and the cost is high. Anthropometric indices might be used to evaluate body fat and its distribution in general population. In chronic kidney disease patients, studies have been indicating that overweight status improves survival rates. On the other...
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Published on Jun 1, 2016in Nutrition in Clinical Practice 2.59
Barbara Perez Vogt5
Estimated H-index: 5
(UNESP: Sao Paulo State University),
Daniela Ponce13
Estimated H-index: 13
(UNESP: Sao Paulo State University),
Jacqueline Socorro Costa Teixeira Caramori15
Estimated H-index: 15
(UNESP: Sao Paulo State University)
Background: Obesity has been considered the key in metabolic syndrome (MetS) development, and fat accumulation may be responsible for the occurrence of metabolic abnormalities in hemodialysis patients. The use of gold-standard methods to evaluate obesity is limited, and anthropometric measures may be the simplest methods. However, no study has investigated the association between anthropometric indexes and MetS in these patients. Therefore, the aim was to determine which anthropometric indexes h...
6 Citations Source Cite
Published on May 1, 2016in European Journal of Clinical Nutrition 3.11
L P Grillo1
Estimated H-index: 1
,
Denise Pretucci Gigante5
Estimated H-index: 5
+ 1 AuthorsF C F de Barros1
Estimated H-index: 1
Childhood stunting and the metabolic syndrome components in young adults from a Brazilian birth cohort study
5 Citations Source Cite
Published on Jan 1, 2016
Fernanda Michielin Busnello4
Estimated H-index: 4
(UHSA: University of Health Sciences Antigua),
Zilda Elisabeth de Albuquerque Santos (UFRGS: Universidade Federal do Rio Grande do Sul), Bruna Pontin (Universidade do Vale do Rio dos Sinos)
Metabolic syndrome (MetS) is a cluster of metabolic disorders, such as abdominal obesity, dyslipidemia, hypertension, and impaired fasting glucose that contribute to increased cardiovascular morbidity and mortality. Dietary lipids have been recognized as contributory factors in the development and the prevention of cardiovascular risk clustering. This review explores the relevant mechanisms involved in the influence of dietary fatty acids on MetS components.
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