Original paper
Inhibition of carnitine palymitoyltransferase1b induces cardiac hypertrophy and mortality in mice
Abstract
Recent reports suggest that short‐term pharmacological carnitine palmitoyltransferase 1 (Cpt1) inhibition improves skeletal muscle glucose tolerance and insulin sensitivity. Although this appears promising for the treatment of diabetes, these Cpt1 inhibitors are not specific to skeletal muscle and target multiple Cpt1 isoforms. To assess the effects of inhibiting the Cpt1b isoform we generated mice with a heart‐ and skeletal muscle‐specific...
Paper Details
Title
Inhibition of carnitine palymitoyltransferase1b induces cardiac hypertrophy and mortality in mice
Published Date
Jan 16, 2014
Volume
16
Issue
8
Pages
757 - 760
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Notes
History