Inhibition of angiotensin-converting enzyme protects endothelial cell against hypoxia/reoxygenation injury
Abstract
Cardiovascular tissue injury in ischemia/reperfusion has been shown to be prevented by angiotensin-converting enzyme (ACE) inhibitors. However, the mechanism on endothelial cells has not been assessed in detail. Cultured human aortic endothelial cells (HAEC) were exposed to hypoxia with or without reoxygenation. Hypoxia enhanced apoptosis along with the activation of caspase-3. Reoxygenation increased lactate dehydrogenase release...
Paper Details
Title
Inhibition of angiotensin-converting enzyme protects endothelial cell against hypoxia/reoxygenation injury
Published Date
Jan 1, 2000
Journal
Volume
11
Issue
4
Pages
257 - 266
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