Dual sgRNAs facilitate CRISPR/Cas9‐mediated mouse genome targeting
Abstract
The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated 9 (Cas9) system is a versatile RNA-guided mammalian genome modification system. One-step generation of mouse genome targeting has been achieved by co-microinjection of one-cell stage embryos with Cas9 mRNA and small/single guide (sg)RNA. Many studies have focused on enhancing the efficiency of this system. In the present study, we report that...
Paper Details
Title
Dual sgRNAs facilitate CRISPR/Cas9‐mediated mouse genome targeting
Published Date
Feb 26, 2014
Journal
Volume
281
Issue
7
Pages
1717 - 1725
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