Primary prevention of diabetes: what can be done and how much can be prevented?

Published on Apr 21, 2005in Annual Review of Public Health10.78
· DOI :10.1146/annurev.publhealth.26.021304.144532
Matthias B. Schulze67
Estimated H-index: 67
Frank B. Hu202
Estimated H-index: 202
▪ Abstract Although it is widely believed that type 2 diabetes mellitus is the result of a complex interplay between genetic and environmental factors, compelling evidence from epidemiologic studies indicates that the current worldwide diabetes epidemic is largely due to changes in diet and lifestyle. Prospective cohort studies and randomized clinical trials have demonstrated that type 2 diabetes can be prevented largely through moderate diet and lifestyle modifications. Excess adiposity is the most important risk factor for diabetes, and thus, maintaining a healthy body weight and avoiding weight gain during adulthood is the cornerstone of diabetes prevention. Increasing physical activity and reducing sedentary behaviors such as prolonged TV watching are important both for maintaining body weight and improving insulin sensitivity. There is increasing evidence that the quality of fat and carbohydrate plays a more important role than does the quantity, and thus, public health strategies should emphasize re...
  • References (155)
  • Citations (233)
Published on Nov 8, 2004in JAMA Internal Medicine20.77
Teresa T. Fung42
Estimated H-index: 42
Matthias B. Schulze67
Estimated H-index: 67
+ 2 AuthorsFrank B. Hu202
Estimated H-index: 202
Background: Although obesity is the most important risk factor for type 2 diabetes, evidence is emerging that certain foods and dietary factors may be associated with diabetes. To examine the association between major dietary patterns and risk of type 2 diabetes mellitus in a cohort of women. Methods:Weprospectivelyassessedtheassociationsbetween major dietary patterns and risk of type 2 diabetes in women. Dietary information was collected in 1984, 1986, 1990, and 1994 from 69554 women aged 38 to...
Published on Sep 8, 2004in JAMA51.27
Amy R. Weinstein6
Estimated H-index: 6
Howard D. Sesso68
Estimated H-index: 68
+ 4 AuthorsJohn Michael Gaziano113
Estimated H-index: 113
ContextPhysical inactivity and body mass index (BMI) are established independent risk factors in the development of type 2 diabetes; however, their comparative importance and joint relationship with diabetes are unclear.ObjectiveTo examine the relative contributions and joint association of physical activity and BMI with diabetes.Design, Setting, and ParticipantsProspective cohort study of 37 878 women free of cardiovascular disease, cancer, and diabetes with 6.9 years of mean follow-up. Weight,...
Published on Sep 1, 2004in Diabetes Care15.27
Yiqing Song41
Estimated H-index: 41
JoAnn E. Manson232
Estimated H-index: 232
+ 1 AuthorsSimin Liu102
Estimated H-index: 102
OBJECTIVE —The aim of this study was to prospectively assess the relation between red meat intake and incidence of type 2 diabetes. RESEARCH DESIGN AND METHODS —Over an average of 8.8 years, we evaluated 37,309 participants in the Women’s Health Study aged ≥45 years who were free of cardiovascular disease, cancer, and type 2 diabetes and completed validated semiquantitative food frequency questionnaires in 1993. RESULTS —During 326,876 person-years of follow-up, we documented 1,558 incident case...
Published on Aug 25, 2004in JAMA51.27
Matthias B. Schulze67
Estimated H-index: 67
(Harvard University),
JoAnn E. Manson232
Estimated H-index: 232
(Harvard University)
+ 4 AuthorsFrank B. Hu202
Estimated H-index: 202
ContextSugar-sweetened beverages like soft drinks and fruit punches contain large amounts of readily absorbable sugars and may contribute to weight gain and an increased risk of type 2 diabetes, but these relationships have been minimally addressed in adults.ObjectiveTo examine the association between consumption of sugar-sweetened beverages and weight change and risk of type 2 diabetes in women.Design, Setting, and ParticipantsProspective cohort analyses conducted from 1991 to 1999 among women ...
Published on Aug 1, 2004in The American Journal of Clinical Nutrition6.57
Matthias B. Schulze67
Estimated H-index: 67
Simin Liu102
Estimated H-index: 102
+ 3 AuthorsFrank B. Hu202
Estimated H-index: 202
Background: Increasing evidence suggests an important role of carbohydrate quality in the development of type 2 diabetes. Objective: Our objective was to prospectively examine the association between glycemic index, glycemic load, and dietary fiber and the risk of type 2 diabetes in a large cohort of young women. Design: In 1991, 91 249 women completed a semiquantitative foodfrequency questionnaire that assessed dietary intake. The women were followed for 8 y for the development of incident type...
Published on Aug 1, 2004in Journal of Internal Medicine6.05
Mats Eliasson40
Estimated H-index: 40
(Umeå University),
Kjell Asplund59
Estimated H-index: 59
(Umeå University)
+ 1 AuthorsBrad Rodu25
Estimated H-index: 25
(UAB: University of Alabama at Birmingham)
Influence of smoking and snus on the prevalence and incidence of type 2 diabetes amongst men : the northern Sweden MONICA study.
Published on Jul 15, 2004in American Journal of Epidemiology4.47
Toshimi Sairenchi23
Estimated H-index: 23
Hiroyasu Iso73
Estimated H-index: 73
+ 5 AuthorsHisayuki Fukutomi16
Estimated H-index: 16
For examination of sex- and age-specific relations between smoking and risk of type 2 diabetes mellitus, 39,528 nondiabetic men and 88,613 nondiabetic women aged 40–79 years who underwent health checkups in Ibarakiken, Japan, in 1993 were followed through 2002. Risk ratios for diabetes according to smoking habits were calculated using a Cox proportional hazards model. Compared with never smokers, the risk ratio for diabetes among current smokers, after adjustment for age, systolic blood pressure...
Published on Jun 15, 2004in American Journal of Epidemiology4.47
Marieke B. Snijder34
Estimated H-index: 34
Marjolein Visser76
Estimated H-index: 76
+ 1 AuthorsJ.C. Seidell83
Estimated H-index: 83
Although previous studies have linked obesity to diabetes, the risks associated with weight gain or changes in body fat distribution have not been fully elucidated. The authors therefore prospectively examined the relations between changes in body weight and body fat distribution (1986–1996) and the subsequent risk of diabetes (1996–2000) among 22,171 men in the Health Professionals Follow-up Study. Weight gain was monotonically related to risk, and for every kilogram of weight gained, risk incr...
Published on May 1, 2004in Diabetes Care15.27
Sarah H. Wild57
Estimated H-index: 57
Gojka Roglic24
Estimated H-index: 24
+ 2 AuthorsHilary King29
Estimated H-index: 29
OBJECTIVE —The goal of this study was to estimate the prevalence of diabetes and the number of people of all ages with diabetes for years 2000 and 2030. RESEARCH DESIGN AND METHODS —Data on diabetes prevalence by age and sex from a limited number of countries were extrapolated to all 191 World Health Organization member states and applied to United Nations’ population estimates for 2000 and 2030. Urban and rural populations were considered separately for developing countries. RESULTS —The preval...
Published on Apr 26, 2004in JAMA Internal Medicine20.77
Gang Hu59
Estimated H-index: 59
Jaana Lindström64
Estimated H-index: 64
+ 5 AuthorsJaakko Tuomilehto84
Estimated H-index: 84
Background Sedentary lifestyle, obesity, and impaired glucose regulation are associated with the risk of type 2 diabetes. However, the joint associations of these risk factors are not known. Methods We prospectively followed up 2017 Finnish men and 2352 Finnish women aged between 45 and 64 years without a history of known or newly diagnosed diabetes at baseline. Single and joint associations of physical activity, body mass index (BMI), and blood glucose levels with risk of type 2 diabetes were e...
Cited By233
Published on May 2, 2019in Journal of Nutrition4.42
Edyta Adamska-Patruno2
Estimated H-index: 2
(UMB: Medical University of Białystok),
Paulina Samczuk4
Estimated H-index: 4
(UMB: Medical University of Białystok)
+ 6 AuthorsAdam Kretowski25
Estimated H-index: 25
(UMB: Medical University of Białystok)
Published on Apr 19, 2019in PLOS ONE2.78
Yujiro Nakayama1
Estimated H-index: 1
Takeru Iijima15
Estimated H-index: 15
+ 5 AuthorsTatsuro Yamaguchi15
Estimated H-index: 15
Published on Apr 1, 2019in Food Quality and Preference3.68
Anna Saba21
Estimated H-index: 21
(Canadian Real Estate Association),
Fiorella Sinesio16
Estimated H-index: 16
(Canadian Real Estate Association)
+ 14 AuthorsF. Gasperi34
Estimated H-index: 34
Abstract The purpose of the current study, was to apply and validate the factor structure of the Health and Taste Attitude Scales in an Italian adult sample of 1224 subjects, recruited on a national basis in order to characterise consumers’ food-related attitudes with weak and strong connotations of health and taste. Both exploratory and confirmatory factor analysis were used to evaluate the factor structure of the three sub-scales of Health (General health interest, Light product interest, Natu...
Published on Mar 1, 2019in Plant Foods for Human Nutrition2.60
Mojca Lunder14
Estimated H-index: 14
(University of Ljubljana),
Irena Roškar3
Estimated H-index: 3
(University of Ljubljana)
+ 1 AuthorsBorut Štrukelj34
Estimated H-index: 34
(University of Ljubljana)
The diet rich in fruits and vegetables reduces the risk of metabolic syndrome, including diabetes development by various mechanisms of action, mainly due to the presence of polyphenolic compounds. Extracts from different conifer species are known to be a rich source of various polyphenols. In the present study we elucidated the in vitro mechanism of anti-diabetic activity of silver fir (Abies alba) wood and bark extracts and compared their activity to non-coniferous sweet chestnut wood extract a...
Published on Feb 25, 2019in Biochemistry and Cell Biology2.01
Heqian Kuang1
Estimated H-index: 1
(UT: University of Tennessee),
Cheng-Hsin Wei (PSU: Pennsylvania State University)+ 3 AuthorsGuoxun Chen17
Estimated H-index: 17
(UT: University of Tennessee)
Whether vitamin A (VA) has a role in the development of metabolic abnormalities associated with intake of a high-fat diet (HFD) is unclear. Sprague-Dawley rats after weaning were fed an isocaloric VA sufficient HFD (VAS-HFD) or a VA deficient HFD (VAD-HFD) for eight weeks. Body mass, food intake, liver and adipose tissue mass, and the hepatic expression levels of key proteins for metabolism were determined. VAD-HFD rats had lower body, liver and epididymal fat mass than VAS-HFD rats. VAD-HFD rat...
Published on Jan 1, 2019
Konstantinos D. Tambalis9
Estimated H-index: 9
(HUA: Harokopio University),
Labros S. Sidossis5
Estimated H-index: 5
(RU: Rutgers University)
In children physical activity (PA) is inversely related to risk factors for chronic diseases such as high blood pressure, fat mass, hyperinsulinemia, insulin resistance, and poor lipid profile, while it helps in the development of healthy bones, muscles, and joints. Moreover, PA influences favorably social and psychological functioning in children. Adequate PA levels in childhood are likely to carry favorable behavioral and biological effects into later life. Promotion of PA, especially in the s...
Published on Dec 1, 2018in Human Genomics2.54
Minjoo Kim10
Estimated H-index: 10
(Yonsei University),
Minkyung Kim11
Estimated H-index: 11
(Yonsei University)
+ 2 AuthorsJong Ho Lee39
Estimated H-index: 39
(Yonsei University)
Background Oxidative stress is associated with the increased risk of hypertension (HTN). This cross-sectional study is aimed to identify the association between the peroxisome proliferator-activated receptor-δ (PPARD) polymorphism and plasma malondialdehyde (MDA), an oxidative stress marker which is related to HTN development, and to determine whether PPARD gene is a candidate gene for HTN.
Published on Nov 20, 2018in Journal of Clinical Medicine
Alessandra N. Bazzano7
Estimated H-index: 7
A. Bazzano1
Estimated H-index: 1
+ 7 AuthorsGang Hu59
Estimated H-index: 59
The burden of illness related to diabetes and its complications is exceedingly high and growing globally. Systematic approaches to managing chronic care are needed to address the complex nature of the disease, taking into account health system structures. This study presents data collected from interviews with physicians, health system administrators, and other healthcare staff about chronic care management for elderly people with diabetes co-morbid with other chronic conditions in light of new ...
Published on Oct 1, 2018in Industrial Crops and Products4.19
Oluwaseun Ruth Alara6
Estimated H-index: 6
(Universiti Malaysia Pahang),
Nour Hamid Abdurahman8
Estimated H-index: 8
(Universiti Malaysia Pahang)
+ 1 AuthorsNour Hamid Azhari1
Estimated H-index: 1
(International University of Africa)
Abstract Diabetes mellitus is a metabolic disorder disease emanating from the inability of body’s response to high glucose levels in the blood. However, the side-effects from consuming synthetic drugs have reduced the effectiveness, thus, the potential of purple fleabane ( Vernonia cinerea ) leaf was investigated using microwave-assisted extraction (MAE) in this study. The influences of extraction factors such as irradiation time, microwave power level, feed/solvent, and ethanol concentration on...
View next paperEffects of Diet and Exercise in Preventing NIDDM in People With Impaired Glucose Tolerance: The Da Qing IGT and Diabetes Study