Use of Transmission Electron Microscopy to Identify Nanocrystals of Challenging Protein Targets

Volume: 111, Issue: 23, Pages: 8470 - 8475
Published: Jun 10, 2014
Abstract
The current practice for identifying crystal hits for X-ray crystallography relies on optical microscopy techniques that are limited to detecting crystals no smaller than 5 μm. Because of these limitations, nanometer-sized protein crystals cannot be distinguished from common amorphous precipitates, and therefore go unnoticed during screening. These crystals would be ideal candidates for further optimization or for femtosecond X-ray protein...
Paper Details
Title
Use of Transmission Electron Microscopy to Identify Nanocrystals of Challenging Protein Targets
DOI
Published Date
Jun 10, 2014
Journal
Volume
111
Issue
23
Pages
8470 - 8475
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