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Mucosal Protection by Phosphatidylcholine

Published on Jan 1, 2012in Digestive Diseases2.908
· DOI :10.1159/000342729
Wolfgang Stremmel75
Estimated H-index: 75
,
Robert Ehehalt31
Estimated H-index: 31
+ 4 AuthorsAnnika Braun10
Estimated H-index: 10
Sources
Abstract
The colonic mucus serves a first barrier towards invasion of commensal bacteria in stools to prevent inflammation. One essential component of intestinal mucus is phosphatidylcholine (PC) which represe
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References41
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Background and Aims Bile analysis has the potential to serve as a surrogate marker for inflammatory and neoplastic disorders of the biliary epithelium and may provide insight into biliary pathophysiology and possible diagnostic markers. We aimed to identify biliary protein markers of patients with primary sclerosing cholangitis (PSC) by a proteomic approach. Methods Bile duct-derived bile samples were collected from PSC patients (n = 45) or patients with choledocholithiasis (n = 24, the control ...
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Abstract Sections from human eye tissue were analyzed with Structured Illumination Microscopy (SIM) using a specially designed microscope setup. In this microscope the structured illumination was generated with a Twyman-Green Interferometer. This SIM technique allowed us to acquire light-optical images of autofluorophore distributions in the tissue with previously unmatched optical resolution. In this work the unique setup of the microscope made possible the application of SIM with three differe...
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Purpose There is increasing evidence that a defect of the gastrointestinal mucosal barrier is important for the development of inflammatory bowel diseases (IBD). The hydrophobicity of the colonic mucosal surface is a measure of its resistance to luminal antigens, e.g. of bacterial origin. Therefore, the purpose of this study was to determine this parameter in patients suffering from IBD.
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Abstract Peroxisome proliferator activated (PPAR)γ plays a critical role in the control of not only adipocyte differentiation, lipid metabolism and immunity but also the barrier functions of epithelial and endothelial cells. In the present study, to investigate effects of PPARγ agonists on the tight junctional barrier of human nasal epithelial cells (HNECs), hTERT-transfected HNECs, which highly express both PPARγ and tight junction proteins, were treated with the PPARγ agonists rosiglitazone an...
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Most multicellular organisms depend on innate immunity, an ancient host defence mechanism found in both plants and animals, to fight microbial infections. Evolutionarily conserved pathways such as the Toll/Toll-like receptor and immune deficiency and tumour necrosis factor receptor pathways generate antimicrobial peptides as part of the innate immune response. This paper provides evidence that the transcription factor FOXO regulates the expression of antimicrobial peptide genes in Drosophila in ...
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#1Irina Treede (Heidelberg University)H-Index: 1
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Background Phosphatidylcholine (PC) is a major lipid of the gastrointestinal mucus layer. We recently showed that mucus from patients suffering from ulcerative colitis has low levels of PC. Clinical studies reveal that the therapeutic addition of PC to the colonic mucus using slow release preparations is beneficial. The positive role of PC in this disease is still unclear; however, we have recently shown that PC has an intrinsic anti-inflammatory property. It could be demonstrated that the exoge...
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Background: Phospholipids are essential for the normal function of the intestinal mucus barrier. The objective of this study was to systematically investigate phospholipids in the intestinal mucus of humans suffering from inflammatory bowel diseases, where a barrier defect is strongly supposed to be pathogenetic. Methods: Optimal mucus recovery was first validated in healthy mice and the method was then transferred to the endoscopic acquisition of ileal and colonic mucus from 21 patients with ul...
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