The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

Volume: 118, Issue: 9, Pages: 3151 - 3159
Published: Sep 2, 2008
Abstract
PKC isoforms tau, alpha, and beta play fundamental roles in the activation of T cells and other immune cell functions. Here we show that the PKC inhibitor AEB071 both abolishes the production of several cytokines by activated human T cells, keratinocytes, and macrophages in vitro and inhibits an acute allergic contact dermatitis response in rats. To translate these findings into humans, single and multiple ascending oral doses of AEB071 were...
Paper Details
Title
The PKC inhibitor AEB071 may be a therapeutic option for psoriasis
Published Date
Sep 2, 2008
Volume
118
Issue
9
Pages
3151 - 3159
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