Sleep Drives Metabolite Clearance from the Adult Brain
Abstract
The conservation of sleep across all animal species suggests that sleep serves a vital function. We here report that sleep has a critical function in ensuring metabolic homeostasis. Using real-time assessments of tetramethylammonium diffusion and two-photon imaging in live mice, we show that natural sleep or anesthesia are associated with a 60% increase in the interstitial space, resulting in a striking increase in convective exchange of...
Paper Details
Title
Sleep Drives Metabolite Clearance from the Adult Brain
Published Date
Oct 18, 2013
Journal
Volume
342
Issue
6156
Pages
373 - 377
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Notes
History