Trajectories of Depression Severity in Clinical Trials of Duloxetine

The high percentage of failed clinical trials in depression may be due to high placebo response rates and the failure of standard statistical approaches to capture heterogeneity in treatment response.To assess whether growth mixture modeling can provide insights into antidepressant and placebo responses in clinical trials of patients with major depression.We reanalyzed clinical trials of duloxetine to identify distinct trajectories of Hamilton...