Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
Abstract
The cell-to-cell transmission of viral resistance is a potential mechanism for amplifying the interferon-induced antiviral response. In this study, we report that interferon-α (IFN-α) induced the transfer of resistance to hepatitis B virus (HBV) from nonpermissive liver nonparenchymal cells (LNPCs) to permissive hepatocytes via exosomes. Exosomes from IFN-α-treated LNPCs were rich in molecules with antiviral activity. Moreover, exosomes from...
Paper Details
Title
Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity
Published Date
Jul 7, 2013
Journal
Volume
14
Issue
8
Pages
793 - 803
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