A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants

Volume: 3, Issue: 10, Pages: 1142 - 1155
Published: Jul 18, 2013
Abstract
Mutations in BRCA1 and BRCA2 account for the majority of hereditary breast and ovarian cancers, and therefore sequence analysis of both genes is routinely performed in patients with early-onset breast cancer. Besides mutations that clearly abolish protein function or are known to increase cancer risk, a large number of sequence variants of uncertain significance (VUS) have been identified. Although several functional assays for BRCA1 VUS have...
Paper Details
Title
A High-Throughput Functional Complementation Assay for Classification of BRCA1 Missense Variants
Published Date
Jul 18, 2013
Volume
3
Issue
10
Pages
1142 - 1155
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