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MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II

Published on Apr 5, 2007in Human Molecular Genetics4.54
· DOI :10.1093/hmg/ddm201
Hariyadarshi Pannu18
Estimated H-index: 18
,
Van Tran-Fadulu11
Estimated H-index: 11
+ 12 AuthorsDianna M. Milewicz56
Estimated H-index: 56
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Abstract
Non-syndromic thoracic aortic aneurysms and dissections (TAADs) are inherited in an autosomal dominant manner in 20% of cases. Familial TAAD is genetically heterogeneous and four loci have been mapped for this disease to date, including a locus at 16p for TAAD associated with patent ductus arteriosus (PDA). The defective gene at the 16p locus has recently been identified as the smooth muscle cell (SMC)-specific myosin heavy chain gene (MYH11). On sequencing MYH11 in 93 families with TAAD alone and three families with TAAD/PDA, we identified novel mutations in two families with TAAD/PDA, but none in families with TAAD alone. Histopathological analysis of aortic sections from two individuals with MYH11 mutations revealed SMC disarray and focal hyperplasia of SMCs in the aortic media. SMC hyperplasia leading to significant lumen narrowing in some of the vessels of the adventitia was also observed. Insulin-like growth factor-1 (IGF-1) was upregulated in mutant aortas as well as explanted SMCs, but no increase in transforming growth factor-b expression or downstream targets was observed. Enhanced expression of angiotensin-converting enzyme and markers of Angiotensin II (Ang II) vascular inflammation (macrophage inflammatory protein-1a and b) were also found. These data suggest that MYH11 mutations are likely to be specific to the phenotype of TAAD/PDA and result in a distinct aortic and occlusive vascular pathology potentially driven by IGF-1 and Ang II.
  • References (38)
  • Citations (168)
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References38
Newest
#1Adrian Recinos (UTMB: University of Texas Medical Branch)H-Index: 10
#2Wanda S. LeJeune (UTMB: University of Texas Medical Branch)H-Index: 13
Last.Allan R. Brasier (UTMB: University of Texas Medical Branch)H-Index: 54
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#1Carolyn Y. Ho (Brigham and Women's Hospital)H-Index: 36
#2Christine E. Seidman (Brigham and Women's Hospital)H-Index: 115
#1Hariyadarshi Pannu (University of Texas Health Science Center at Houston)H-Index: 18
#2Van Tran Fadulu (University of Texas Health Science Center at Houston)H-Index: 3
Last.Hazim J. Safi (University of Texas Health Science Center at Houston)H-Index: 60
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#2Haruhito Adam Uchida (Okayama University)H-Index: 12
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#1Stephanie Wallace (University of Texas Health Science Center at Houston)H-Index: 3
#2Ellen S. Regalado (University of Texas Health Science Center at Houston)H-Index: 24
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#1Damian Balmforth (St Bartholomew's Hospital)H-Index: 3
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