The role of in vivo Ca²⁺ signals acting on Ca²⁺–calmodulin‐dependent proteins for skeletal muscle plasticity

Skeletal muscle fibres are highly heterogeneous regarding size, metabolism and contractile function. They also show a large capacity for adaptations in response to alterations in the activation pattern. A major part of this activity‐dependent plasticity relies on transcriptional alterations controlled by intracellular Ca 2+ signals. In this review we discuss how intracellular Ca 2+ fluctuations induced by activation patterns likely to occur in...