Sericin cream reduces pruritus in hemodialysis patients: a randomized, double-blind, placebo-controlled experimental study

Published on Dec 1, 2012in BMC Nephrology2.088
· DOI :10.1186/1471-2369-13-119
Pornanong Aramwit23
Estimated H-index: 23
(Chula: Chulalongkorn University),
Orathai Keongamaroon1
Estimated H-index: 1
(Chula: Chulalongkorn University)
+ 2 AuthorsOuppatham Supasyndh12
Estimated H-index: 12
Background Uremic pruritus (UP) is a significant complication in ESRD patients and substantially impairs their quality of life. UP is considered to be a skin manifestation of chronic inflammation. Because sericin can suppress the release of pro-inflammatory cytokines, the purpose of this study was to investigate the short-term safety and efficacy of sericin cream for treating UP in hemodialysis patients.
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Pruritus is a common symptom in patients with end-stage renal disease (ESRD). In older series, up to 90% of patients were afflicted with pruritus, but now between 20% and 50% are affected.1-3 Pruritus occurs independent of the cause of the ESRD, and patients on both peritoneal and hemodialysis experience pruritus at similar rates. All races, both genders and all ages can develop ESRD pruritus.4 Nephrologists have recognized and documented significant impact of itch on ESRD patients’ quality of l...
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The present study investigated the chemical properties and antityrosinase activities of SS (silk sericin) extracted from different Thai silk strains via various extraction methods. Different silk strains contain distinct SS with various amino acid compositions, which are significantly influenced by the extraction method used. Urea extraction of SS was the only method that provided clearly distinguishable bands and had the most significant impact on SS conformation as illustrated by FTIR (Fourier...
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Chronic kidney disease (CKD)-associated pruritus is a significant clinical symptom affecting more than 50% of patients on hemodialysis. Restricted by the availability of effective therapeutic options, the management of CKD-associated pruritus remains a treatment challenge. Evaluating research in this area is difficult, as most studies are not comparable due to differing methodologies and study designs, limited number of patients, and the lack of standardized measures. The most frequently used th...
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Chronic itch associated with systemic diseases continues to be one of the most bothersome dermatological symptoms accompanying end-stage renal disease (ESRD), chronic liver diseases, and lymphoma. The International Forum for the Study of Itch has recently issued a consensus paper on different types of chronic pruritus, including pruritus in systemic diseases that can present with or without secondary skin changes.1Various types of itch have been described based on the origin of the itch, which c...
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#1Hector Alvarado Verduzco (Columbia University)
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Background and objectives: Chronic kidney disease (CKD)-associated pruritus is a common and disturbing condition which has a negative impact on sleep quality, as well as overall health-related quality of life of patients receiving hemodialysis. To date, no systematic review has been undertaken, and there is a lack of concise evidence that statistically quantifies the impact of pruritus based on published data. Materials and Methods: A systematic search was done for original articles published in...
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