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Sericin cream reduces pruritus in hemodialysis patients: a randomized, double-blind, placebo-controlled experimental study

Published on Dec 1, 2012in BMC Nephrology2.088
· DOI :10.1186/1471-2369-13-119
Pornanong Aramwit23
Estimated H-index: 23
(Chula: Chulalongkorn University),
Orathai Keongamaroon1
Estimated H-index: 1
(Chula: Chulalongkorn University)
+ 2 AuthorsOuppatham Supasyndh12
Estimated H-index: 12
Abstract
Background Uremic pruritus (UP) is a significant complication in ESRD patients and substantially impairs their quality of life. UP is considered to be a skin manifestation of chronic inflammation. Because sericin can suppress the release of pro-inflammatory cytokines, the purpose of this study was to investigate the short-term safety and efficacy of sericin cream for treating UP in hemodialysis patients.
  • References (52)
  • Citations (23)
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References52
Newest
Introduction: We aimed to assess quality of life (QOL) among Saudi hemodialysis (HD) patients and the impact on the QOL of a certain demographic and clinical factors. Methods: The QOL was assessed using an Arabic version of Kidney Disease Quality of Life Instrument Short Form (KDQOL-SF). Mean scores were compared for individual domain scores and for the three composite summary scores, namely the mental component score (MCS), the physical component score (PCS) and kidney-disease component score (...
16 CitationsSource
#1Meital Portugal-Cohen (HUJI: Hebrew University of Jerusalem)H-Index: 8
#2Miriam OronH-Index: 11
Last. Ron Kohen (HUJI: Hebrew University of Jerusalem)H-Index: 38
view all 10 authors...
Abstract Background/Aims Cutaneous manifestations are common in hemodialysis (HD) patients with chronic renal failure (CRF). Associated with uremia, pruritus is a frequently observed symptom in CRF patients and increases with deteriorating renal function. Skin hydrophilic biomarkers (SHB) may be altered in CRF compared to healthy controls. Methods A noninvasive skin wash sampling technique to detect the expression of SHB, by measuring their secretion on skin surface, was used on HD patients and ...
7 CitationsSource
#1Timothy G. Berger (UCSF: University of California, San Francisco)H-Index: 49
#2Martin Steinhoff (UCSF: University of California, San Francisco)H-Index: 66
Pruritus is a common symptom in patients with end-stage renal disease (ESRD). In older series, up to 90% of patients were afflicted with pruritus, but now between 20% and 50% are affected.1-3 Pruritus occurs independent of the cause of the ESRD, and patients on both peritoneal and hemodialysis experience pruritus at similar rates. All races, both genders and all ages can develop ESRD pruritus.4 Nephrologists have recognized and documented significant impact of itch on ESRD patients’ quality of l...
24 CitationsSource
#1Pornanong Aramwit (Chula: Chulalongkorn University)H-Index: 23
#2Tippawan Siritientong (Chula: Chulalongkorn University)H-Index: 8
Last. Teerapol Srichana (PSU: Prince of Songkla University)H-Index: 28
view all 4 authors...
Abstract A porous-three-dimensional scaffold shows several advantages in terms of tissue engineering since it can provide a framework for cells to attach, proliferate and form an extracellular matrix. Sericin, a by-product from the silk industry, can form a three-dimensional scaffold with PVA after freeze-drying but has a fragile structure. Glycerin (as a plasticizer) and genipin (a crosslinking agent) are necessary to make a strong and stable matrix. Our objective was to investigate the propert...
88 CitationsSource
Background and objectives: Although uremic pruritus (UP) is a highly prevalent complication of chronic kidney disease, it remains poorly characterized. There have been no longitudinal studies of natural history, and no health-related quality of life (HR-QOL) instruments have been developed for UP. The objectives of this study were to describe the natural history of UP, to compare rating scales of itching intensity, and to assess usefulness and validity of HR-QOL instruments for UP. Design, setti...
93 CitationsSource
#1Jamison D. Feramisco (UCSF: University of California, San Francisco)H-Index: 11
#2Timothy G. Berger (UCSF: University of California, San Francisco)H-Index: 49
Last. Martin Steinhoff (UCSF: University of California, San Francisco)H-Index: 66
view all 3 authors...
Pruritus remains a significant problem facing dermatologists and can be associated with various dermatoses and systemic derangements. At times, one can treat the underlying cutaneous or systemic process to alleviate itch. However, it is frequently challenging to identify the cause of a patient's itch and, in this situation, even more difficult to manage the symptom effectively. In this article, the authors discuss the approach to a patient with generalized pruritus without clinically obvious der...
19 CitationsSource
#1Pornanong Aramwit (Chula: Chulalongkorn University)H-Index: 23
#2Sorada KanokpanontH-Index: 20
Last. Teerapol SrichanaH-Index: 28
view all 4 authors...
Silk sericin (SS) can accelerate cell proliferation and attachment; however, SS can be extracted by various methods, which result in SS exhibiting different physical and biological properties. We found that SS produced from various extraction methods has different molecular weights, zeta potential, particle size and amino acid content. The MTT assay indicated that SS from all extraction methods had no toxicity to mouse fibroblast cells at concentrations up to 40 μg/mL after 24 h incubation, but ...
138 CitationsSource
#1Pornanong Aramwit (Chula: Chulalongkorn University)H-Index: 23
#2Siriporn Damrongsakkul (Chula: Chulalongkorn University)H-Index: 22
Last. Teerapol Srichana (PSU: Prince of Songkla University)H-Index: 28
view all 4 authors...
The present study investigated the chemical properties and antityrosinase activities of SS (silk sericin) extracted from different Thai silk strains via various extraction methods. Different silk strains contain distinct SS with various amino acid compositions, which are significantly influenced by the extraction method used. Urea extraction of SS was the only method that provided clearly distinguishable bands and had the most significant impact on SS conformation as illustrated by FTIR (Fourier...
60 CitationsSource
#1Mettang MH-Index: 1
#2Weisshaar EH-Index: 1
Chronic kidney disease (CKD)-associated pruritus is a significant clinical symptom affecting more than 50% of patients on hemodialysis. Restricted by the availability of effective therapeutic options, the management of CKD-associated pruritus remains a treatment challenge. Evaluating research in this area is difficult, as most studies are not comparable due to differing methodologies and study designs, limited number of patients, and the lack of standardized measures. The most frequently used th...
18 Citations
Chronic itch associated with systemic diseases continues to be one of the most bothersome dermatological symptoms accompanying end-stage renal disease (ESRD), chronic liver diseases, and lymphoma. The International Forum for the Study of Itch has recently issued a consensus paper on different types of chronic pruritus, including pruritus in systemic diseases that can present with or without secondary skin changes.1Various types of itch have been described based on the origin of the itch, which c...
55 CitationsSource
Cited By23
Newest
#1Hector Alvarado Verduzco (Columbia University)
#2Shayan Shirazian (Columbia University)H-Index: 7
Abstract Chronic kidney disease associated pruritus (CKD-aP) is a common, troubling and in some cases debilitating problem for patients with CKD and ESRD. Despite a prevalence rate of approximately 20% in CKD and 40% in ESRD, and a clear association with poorer psychosocial and medical outcomes, this condition is often under-reported by patients and overlooked by health care providers. This is likely due, in part, to uncertainty regarding its pathogenesis and treatment. Most commonly CKD-aP is a...
Source
#1Anabela VeigaH-Index: 1
#2Filipa CastroH-Index: 6
Last. Ana OliveiraH-Index: 21
view all 4 authors...
Calcium phosphates (CaPs) have been widely used in the field of biomedical engineering as bone graft substitutes or as carriers for drug delivery applications. Recent developments have focused on combining CaPs with proteins to obtain functional biomaterials that accommodate a broader spectrum of functional requirements. Silk sericin was considered an unutilized protein by-product from the textile industry, generating tons of residues every year. However, much effort has been dedicated to its re...
Source
#1Inayat Ur RehmanH-Index: 3
#2Tahir Ali ChohanH-Index: 4
Last. Tahir Mehmood KhanH-Index: 15
view all 4 authors...
Background and objectives: Chronic kidney disease (CKD)-associated pruritus is a common and disturbing condition which has a negative impact on sleep quality, as well as overall health-related quality of life of patients receiving hemodialysis. To date, no systematic review has been undertaken, and there is a lack of concise evidence that statistically quantifies the impact of pruritus based on published data. Materials and Methods: A systematic search was done for original articles published in...
Source
#1Nitin H. SalunkheH-Index: 2
#2Namdeo JadhavH-Index: 6
Last. Prafulla B. ChoudhariH-Index: 7
view all 4 authors...
The purpose of the present investigation was to analyze devitrification of amorphous drugs such as lornoxicam, meloxicam, and felodipine in the presence of sericin. The binary solid dispersions comprising varying mass ratios of drug and sericin were subject to amorphization by spray drying, solvent evaporation, ball milling, and physical mixing. Further, obtained solid dispersions (SDs) were characterized by HPLC, ATR-FTIR, H1NMR, molecular docking, accelerated stability study at 40°C and 75 ± 2...
Source
#1Su Jin Kim (KNU: Kyungpook National University)H-Index: 1
#2In Chul Um (KNU: Kyungpook National University)H-Index: 17
Silk sericin has been studied for application in the biomedical and cosmetic fields, given its good water retention and wound-healing properties. Although sericin can be obtained by extraction in hot water, this leads to molecular degradation. Recently, it was reported that raw silk can be used as a binder to prepare non-woven silk fabrics using character of sericin. Therefore, a better understanding of the characteristics of raw sericin is required for more effective utilization. In the present...
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#1Supamas Napavichayanun (Chula: Chulalongkorn University)H-Index: 4
#2Sumate Ampawong (MU: Mahidol University)H-Index: 6
Last. Pornanong Aramwit (Chula: Chulalongkorn University)H-Index: 23
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Bacterial cellulose wound dressings containing silk sericin and PHMB (BCSP) were developed in our previous studies. It had good physical properties, efficacy, and safety. For further use as a medical material, this dressing was investigated for its efficacy and safety in split-thickness skin graft (STSG) donor-site wound treatment compared to Bactigras® (control). Moreover, the inflammatory responses to both dressings were also deeply investigated. For in vivo study, expressions of anti-inflamma...
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#1Nitin H. SalunkheH-Index: 2
#2Namdeo JadhavH-Index: 6
Last. Adhikrao D. Jadhav (Shivaji University)H-Index: 1
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Abstract The aim of present attempt deals with preparation of binary dispersion of sericin, waste of sericulture industry in order to enhance solubility and dissolution of poorly soluble drugs. Solid dispersions (SDs) of BCS-II drugs were prepared by spray drying, solvent evaporation, ball milling and physical mixing in ratio of drug:sericin (1:0.5, 1:1, 1:1.5, 1:2, 1:2.5 and 1:3). Further, SDs were investigated by solubility, ATR-FTIR, XRD, DSC, micromeritics and tablettability, surface morphol...
1 CitationsSource
#1G. W. M. Millington (NNUH: Norfolk and Norwich University Hospital)H-Index: 7
#2A. Collins (NNUH: Norfolk and Norwich University Hospital)H-Index: 1
Last. Nick J. Levell (NNUH: Norfolk and Norwich University Hospital)H-Index: 19
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17 CitationsSource
#1Farogh Ahsan (Integral University)H-Index: 3
#2Tarique Mahmood Ansari (Integral University)H-Index: 2
Last. Paramdeep Bagga (Integral University)H-Index: 5
view all 4 authors...
Silks are naturally occurring polymers that have been used clinically as sutures for hundreds of years. It’s so for obtained from insects or worms, silk consists of a filament core protein, termed fibroin, and a glue-like coating made up of sericin proteins. An important component of silk has an extended history of being discarded as a waste in the course of silk processing. The cost of sericin for tissue engineering is underestimated and its capability in using as regenerative remedy has simply...
5 CitationsSource