Horse chestnut seed extract for chronic venous insufficiency

Background Conservative therapy of chronic venous insufficiency (CVI) consists largely of compression treatment. However, this often causes discomfort and has been associated with poor compliance. Therefore, oral drug treatment is an attractive option. This is an update of a Cochrane review first published in 2002 and updated in 2004, 2006, 2008 and 2010. Objectives To review the efficacy and safety of oral horse chestnut seed extract (HCSE)...