β-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations
Abstract
The discovery of somatic mutations in EGFR and development of EGFR tyrosine kinase inhibitors (TKI) have revolutionized treatment for lung cancer. However, resistance to TKIs emerges in almost all patients and currently no effective treatment is available. Here, we show that β-catenin is essential for development of EGFR-mutated lung cancers. β-Catenin was upregulated and activated in EGFR-mutated cells. Mutant EGFR preferentially bound to and...
Paper Details
Title
β-Catenin Contributes to Lung Tumor Development Induced by EGFR Mutations
Published Date
Oct 14, 2014
Journal
Volume
74
Issue
20
Pages
5891 - 5902
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