Depression Subtypes in Predicting Antidepressant Response: A Report From the iSPOT-D Trial

Objective: The study aims were 1) to describe the proportions of individuals who met criteria for melancholic, atypical, and anxious depressive subtypes, as well as subtype combinations, in a large sample of depressed outpatients, and 2) to compare subtype profiles on remission and change in depressive symptoms after acute treatment with one of three antidepressant medications. Method: Participants 18–65 years of age (N=1,008) who met criteria...