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Finnish Institute of Occupational Health (FIOH): Prevention and detection of asbestos‐related diseases, 1987–2005

Published on Mar 1, 2006in American Journal of Industrial Medicine 1.90
· DOI :10.1002/ajim.20282
Matti S. Huuskonen3
Estimated H-index: 3
(UH: University of Helsinki),
Jorma Rantanen14
Estimated H-index: 14
(Finnish Institute of Occupational Health)
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Abstract
Background Between 1987 and 1992, the Finnish Institute of Occupational Health (FIOH) initiated and implemented the Asbestos Program that aimed at reducing asbestos-related risks. It was a cooperative effort between government authorities, labor market organizations, and health care and labor protection personnel. Methods During the Program and its follow-up since 1993 several preventive actions were taken, and considerable new legislation and official instructions were issued. Results Approximately 200,000 people in Finland have been exposed to asbestos in their work. Through the cooperative efforts of government, labor, health care and worker protection programs, the import of asbestos was ceased in 1993 with a few exceptions. Almost all imports ceased in 2005 following European Union directives. Regulation of asbestos abatement companies has been greatly increased. The occupational exposure limit has been reduced from 2.0 fibers/cm3 to the present 0.1 fibers/cm3. Asbestos-related diseases are closely monitored and education of health care providers regarding the occupational source of these conditions is now emphasized. Conclusions The success of the primary goal of the Program, a reduction in asbestos-related morbidity, will not be fully realized for many decades. Am. J. Ind. Med. 49:215–220, 2006. © 2006 Wiley-Liss, Inc.
  • References (17)
  • Citations (10)
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References17
Newest
Published on Jan 1, 2005
Yukinori Kusaka18
Estimated H-index: 18
,
Kurt G. Hering9
Estimated H-index: 9
,
John E. Parker16
Estimated H-index: 16
Classification System.- A Glossary of HRCT Terms.- Coding CT-Classification in Occupational and Environmental Respiratory Disease (OERD).- Technical Aspects and Imaging Parameters in HRCT.- Practice and Study Protocol.- Radiation Exposure and Risk Assessment in HRCT.- Application of the International Classification of HRCT for the Occupational Lung Diseases.- ILO International Classifications of Radiographs of Pneumoconioses - Past, Present and Future -.- CT Images.- Pleural Diseases.- Parenchym...
Published on Dec 1, 2004in Pathology 3.16
Douglas W. Henderson26
Estimated H-index: 26
(Flinders Medical Centre),
K. Rödelsperger12
Estimated H-index: 12
(University of Giessen)
+ 1 AuthorsJames Leigh43
Estimated H-index: 43
(USYD: University of Sydney)
Summary Despite an extensive literature, the relationship between asbestos exposure and lung cancer remains the subject of controversy, related to the fact that most asbestos- associated lung cancers occur in those who are also cigarette smokers: because smoking represents the strongest identifiable lung cancer risk factor among many others, and lung cancer is not uncommon across industrialised societies, analysis of the combined (synergistic) effects of smoking and asbestos on lung cancer risk ...
Antti Tossavainen1
Estimated H-index: 1
AbstractIn Western Europe, Scandinavia, North America, and Australia the manufacture and use of asbestos products peaked in the 1970s. Current incidences of mesothelioma range from 14 to 35 cases/million/year in 11 industrialized countries that had used asbestos 2.0 to 5.5 kg/capita/year about 25 years earlier. A significant linear correlation (r = 0.80, p 0.01) exists between the two variables. Accordingly, about 170 tons of produced and consumed asbestos will cause at least one death from meso...
Published on Jan 1, 2003in Chest 9.66
Peter B. Bach53
Estimated H-index: 53
(MSK: Memorial Sloan Kettering Cancer Center),
Michael J. Kelley42
Estimated H-index: 42
(Duke University)
+ 1 AuthorsDc McCrory51
Estimated H-index: 51
(Duke University)
Study objectives To review the available data on the early detection of lung cancer, with a focus on three technologies: chest x-ray (CXR), sputum cytology, and low-dose CT (LDCT) scanning. Design, setting, participants Review of published clinical studies of early detection technologies. The best available evidence on each topic was selected for analysis. Randomized trials were used to evaluate CXR and sputum cytology. Cohort studies, as well as studies providing evidence regarding rates of ove...
Published on Jan 1, 2003in Chest 9.66
Peter B. Bach53
Estimated H-index: 53
(MSK: Memorial Sloan Kettering Cancer Center),
Michael J. Kelley42
Estimated H-index: 42
(Duke University)
+ 1 AuthorsDc McCrory51
Estimated H-index: 51
(Duke University)
Study objectives To review the available data on the early detection of lung cancer, with a focus on three technologies: chest x-ray (CXR), sputum cytology, and low-dose CT (LDCT) scanning. Design, setting, participants Review of published clinical studies of early detection technologies. The best available evidence on each topic was selected for analysis. Randomized trials were used to evaluate CXR and sputum cytology. Cohort studies, as well as studies providing evidence regarding rates of ove...
Published on Jan 1, 2003in Chest 9.66
Peter B. Bach53
Estimated H-index: 53
(MSK: Memorial Sloan Kettering Cancer Center),
Dennis E. Niewoehner43
Estimated H-index: 43
,
William C. Black9
Estimated H-index: 9
(Dartmouth–Hitchcock Medical Center)
Although virtually all individuals with advanced lung cancer succumb to the disease, a substantial portion of individuals diagnosed at an earlier stage can be cured. This dichotomy has provoked interest in lung cancer screening. To date, randomized controlled trials of chest x-ray and sputum cytology have failed to demonstrate that screening with either modality decreases lung cancer mortality; neither of these technologies can be recommended. Early studies of lung cancer screening with low-dose...
Published on Jan 1, 2002in Lung Cancer 4.60
Mia Tiitola1
Estimated H-index: 1
(HYKS: Helsinki University Central Hospital),
L. Kivisaari32
Estimated H-index: 32
(HYKS: Helsinki University Central Hospital)
+ 5 AuthorsTapio Vehmas29
Estimated H-index: 29
(Finnish Institute of Occupational Health)
Abstract We conducted a computed tomography (CT) screening for lung cancer in a high-risk population. Six hundred and two workers (38–81 years, 97% smokers) with asbestos-related occupational disease were screened using spiral CT and chest radiography. The national cancer registry was checked for possible false negative cases. The screening detected 111 patients with non-calcified nodules >0.5 cm in diameter and 66 of them were referred for further hospital examination. We found five lung cancer...
Published on Apr 1, 2001in Scandinavian Journal of Work, Environment & Health 3.49
Olli Huuskonen4
Estimated H-index: 4
,
L. Kivisaari32
Estimated H-index: 32
+ 3 AuthorsTapio Vehmas29
Estimated H-index: 29
Objectives This study tested a new high-resolution computed tomography (HRCT) scoring method for asbestos-induced parenchymal changes in the lung. Methods HRCT scans of 602 asbestos-exposed workers and 49 referents were reviewed by 3 radiologists. Structured forms were filled out for a semiquantitative HRCT fibrosis score based on several specified parenchymal abnormalities scored separately. Observer agreement was studied with the use of the quadratic-weighted kappa (kappa qw ). The HRCT fibros...
Cited By10
Newest
Published on Mar 1, 2015in Experimental Cell Research 3.33
Jenni A. Tamminen4
Estimated H-index: 4
(UH: University of Helsinki),
Miao Yin2
Estimated H-index: 2
(UH: University of Helsinki)
+ 5 AuthorsKatri Koli26
Estimated H-index: 26
(UH: University of Helsinki)
Abstract Activin-A and activin-B, members of the TGF-β superfamily, are regulators of reproductive functions, inflammation and wound healing. These dimeric molecules regulate various cellular activities such as proliferation, migration and suvival. Malignant mesothelioma is an asbestos exposure related tumor affecting mainly pleura and it usually has a dismal prognosis. Here, we demonstrate that both activin-A and -B are abundantly expressed in mesothelioma tumor tissue as well as in cultured pr...
Published on Nov 1, 2013
IN FINNISH – tIIvIStELMa 3 ABStRAct 6 cONtENtS 9 LISt OF ORIgINAL pUBLIcAtIONS 12 ABBREvIAtIONS 13
Published on Aug 1, 2013
Jenni A. Tamminen4
Estimated H-index: 4
,
Ville Parviainen7
Estimated H-index: 7
+ 10 AuthorsGerhard Sengle17
Estimated H-index: 17
Malignant mesothelioma is a form of cancer that is highly resistant to conventional cancer therapy for which no major therapeutic advances have been introduced. Here, we identify gremlin-1, a known bone morphogenetic protein inhibitor crucial for embryonic development, as a potential therapeutic target for mesothelioma. We found high expression levels of gremlin-1 in the mesothelioma tumor tissue, as well as in primary mesothelioma cells cultured from pleural effusion samples. Downregulation of ...
Published on Jul 1, 2012in Journal of Cellular Biochemistry 3.45
Jenni A. Tamminen4
Estimated H-index: 4
(UH: University of Helsinki),
Marjukka Myllärniemi28
Estimated H-index: 28
(UH: University of Helsinki)
+ 2 AuthorsKatri Koli26
Estimated H-index: 26
(UH: University of Helsinki)
The inhalation of asbestos fibers is considered to be highly harmful, and lead to fibrotic and/or malignant disease. Epithelial-to-mesenchymal transition (EMT) is a common pathogenic mechanism in asbestos associated fibrotic (asbestosis) and malignant lung diseases. The characterization of molecular pathways contributing to EMT may provide new possibilities for prognostic and therapeutic applications. The role of asbestos as an inducer of EMT has not been previously characterized. We exposed cul...
Published on Jan 1, 2010in International Journal of Hygiene and Environmental Health 4.38
Beate Pesch33
Estimated H-index: 33
(RUB: Ruhr University Bochum),
Dirk Taeger21
Estimated H-index: 21
(RUB: Ruhr University Bochum)
+ 11 AuthorsVolker Neumann5
Estimated H-index: 5
(RUB: Ruhr University Bochum)
Abstract The objective of this analysis was the estimation of the cancer risks of asbestos and asbestosis in a surveillance cohort of high-exposed German workers. A group of 576 asbestos workers was selected for high-resolution computer tomography of the chest in 1993-1997. A mortality follow-up was conducted through 2007. Standardised mortality ratios (SMRs) were calculated and Poisson regression was performed to assess mesothelioma risks. A high risk was observed for pleural mesothelioma (SMR ...
Monica Amati16
Estimated H-index: 16
,
Marco Tomasetti23
Estimated H-index: 23
+ 3 AuthorsLory Santarelli22
Estimated H-index: 22
Abstract Epidemiological studies have shown that mortality from malignant mesothelioma (MM) and lung cancer have increased with increasing cumulative exposure to asbestos. To investigate whether tumour-related biomarkers can contribute towards the evaluation of the carcinogenic risk in populations exposed to asbestos, the DNA adduct 8-hydroxy-2′-deoxyguanosine (8OHdG), interleukine-6 (IL-6), platelet-derived growth factor (PDGF-BB), hepatocyte growth factor (HGF), basic fibroblast growth factor ...
Published on Jan 1, 2007in Industrial Health 1.32
Claudio Bianchi13
Estimated H-index: 13
,
Tommaso Bianchi7
Estimated H-index: 7
Mesothelioma incidence varies markedly from one country to another. The highest annual crude incidence rates (about 30 cases per million) are observed in Australia, Belgium, and Great Britain. A lot of data indicate a relationship between mesothelioma and asbestos. The hot areas for mesothelioma exactly correspond to the sites of industries with high asbestos use, such as shipbuilding and asbestos-cement industry. However, in many countries with high asbestos consumption, mesothelioma incidence ...
Published on Nov 1, 2006in Lung Cancer 4.60
Eeva Kettunen15
Estimated H-index: 15
(Finnish Institute of Occupational Health),
Kaisa Salmenkivi27
Estimated H-index: 27
(HYKS: Helsinki University Central Hospital)
+ 7 AuthorsSisko Anttila42
Estimated H-index: 42
(HYKS: Helsinki University Central Hospital)
Summary Lung cancer specimens display recurrent copy number aberrations in distinguished chromosomal regions as compared with normal lung cells. Such alterations have been utilized in design of fluorescence in situ hybridization (FISH) probe sets in attempts to improve the cytological diagnosis of lung cancer. One of such probe sets, LAVysion™, detects copy number changes in the centromeric region of chromosome 6 (CEP6), and regions 5p15, 8q24, and 7p12, often gained in lung cancer. Methods We e...
Published on Sep 27, 2006in European Respiratory Journal 11.81
Tuula Vierikko6
Estimated H-index: 6
,
Ritva Järvenpää15
Estimated H-index: 15
+ 12 AuthorsSeppo Saarelainen21
Estimated H-index: 21
The objective of the present study is to determine the feasibility of chest computed tomography (CT) in screening for lung cancer among asbestos-exposed workers. In total, 633 workers were included in the present study and were examined with chest radiography and high-resolution CT (HRCT). A total of 180 current and ex-smokers (cessation within the previous 10 yrs) were also screened with spiral CT. Noncalcified lung nodules were considered positive findings. The incidental CT findings not relat...