Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking
Abstract
The formation of mature secretory granules is essential for proper storage and regulated release of hormones and neuropeptides. In pancreatic β cells, cholesterol accumulation causes defects in insulin secretion and may participate in the pathogenesis of type 2 diabetes. Using a novel cholesterol analog, we show for the first time that insulin granules are the major sites of intracellular cholesterol accumulation in live β cells. This is...
Paper Details
Title
Cholesterol Accumulation Increases Insulin Granule Size and Impairs Membrane Trafficking
Published Date
Sep 13, 2012
Journal
Volume
13
Issue
11
Pages
1466 - 1480
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Notes
History