Structural basis for activation of the complement system by C4 cleavage

Published on Nov 1, 2012in Immunobiology2.798
· DOI :10.1016/j.imbio.2012.08.217
Gregers R. Andersen36
Estimated H-index: 36
(AU: Aarhus University),
Rune T. Kidmose6
Estimated H-index: 6
(AU: Aarhus University)
+ 7 AuthorsPéter Gál32
Estimated H-index: 32
(MTA: Hungarian Academy of Sciences)
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  • Citations (2)
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Growing evidence suggests a prominent role of the complement system in the pathogenesis of cardio- and cerebrovascular diseases (CVD). Mannan-binding lectin-associated serine proteases (MASPs) MASP-1 and MASP-2 of the complement lectin pathway contribute to clot formation and may represent an important link between inflammation and thrombosis. MBL-associated protein MAp44 has shown cardioprotective effects in murine models. However, MAp44 has never been measured in patients with CVD and data on ...
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Complement is a part of innate immunity that has a critical role in the protection against microbial infections, bridges the innate with the adaptive immunity and initiates inflammation. Activation of the complement, by specific recognition of molecular patterns presented by an activator, for example, a pathogen cell, in the classical and lectin pathways or spontaneously in the alternative pathway, leads to the opsonization of the activator and the production of pro-inflammatory molecules such a...
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