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Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults

Published on Jan 1, 2015
Ralf Nass18
Estimated H-index: 18
,
Suzan S. Pezzoli22
Estimated H-index: 22
+ 7 AuthorsMichael O. Thorner69
Estimated H-index: 69
Abstract
The present invention provides synthetic compounds, antibodies that recognize and bind to these compounds, polynucleotides that encode these compounds, and immune effector cells raised in response to presentation of these epitopes. The invention further provides methods for inducing an immune response and administering immunotherapy to a subject by delivering the compositions of the invention.
  • References (47)
  • Citations (7)
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References47
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#1M. Elbornsson (Sahlgrenska University Hospital)H-Index: 2
#2G. Götherström (Sahlgrenska University Hospital)H-Index: 5
Last. Johan SvenssonH-Index: 33
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There are few studies that have determined the effects of long-term GH replacement on bone mineral density (BMD) in GH-deficient (GHD) adults. In this study, the effects of 10 years of GH replacement on BMD were assessed in 87 GHD adults using dual energy X-ray absorptiometry (DEXA). The results show that GH replacement induced a sustained increase in BMD at all the skeletal sites measured. Introduction: Little is known of the effect of more than 5 years of GH replacement therapy on bone metabol...
102 CitationsSource
Background. Few studies have evaluated prospectively age-related body composition changes and their relationships with worsening disability in the elderly population. Methods. Ninety-seven women and 62 men aged 71.4 ± 2.2 and 71.6 ± 2.2 years, respectively, at baseline underwent dual-energy x-ray absorptiometry determinations at baseline and at 2- and 5.5-year follow-up intervals to measure total body and leg fat (FM) and total, appendicular, and leg fat-free mass (FFM). Height, weight, body mas...
98 CitationsSource
There is now a large body of evidence that weight loss in older persons not only increases mortality, but also increases the incidence of hip fracture, functional deterioration and institutionalization. Weight loss is a central component of frailty. There is evidence that it is not only muscle, but also fat loss that leads to these deleterious effects. The reasons why fat loss can be harmful in older persons are reviewed. There are four major causes of weight loss in older persons viz. anorexia,...
139 CitationsSource
#1David R. Thomas (SLU: Saint Louis University)H-Index: 32
Summary A loss of body weight or skeletal muscle mass is common in older persons and is a harbinger of poor outcome. Involuntary weight loss can be categorized into three primary etiologies of starvation, sarcopenia, and cachexia. Starvation results in a loss of body fat and non-fat mass due to inadequate intake of protein and energy. Sarcopenia is associated with a reduction in muscle mass and strength occurring with normal aging, associated with a reduction in motor unit number and atrophy of ...
330 CitationsSource
#2Keiji IidaH-Index: 23
Last. Michael O. ThornerH-Index: 69
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Phosphoinositide (PI) 3-kinase is involved in insulin-mediated effects on glucose uptake, lipid deposition, and adiponectin secretion from adipocytes. Genetic disruption of the p85α regulatory subunit of PI 3-kinase increases insulin sensitivity, whereas elevated p85α levels are associated with insulin resistance through PI 3-kinase–dependent and –independent mechanisms. Adipose tissue plays a critical role in the antagonistic effects of growth hormone (GH) on insulin actions on carbohydrate and...
115 CitationsSource
#1Hau Liu (Stanford University)H-Index: 12
#2Dena M. Bravata (Stanford University)H-Index: 31
Last. Andrew R. Hoffman (Stanford University)H-Index: 71
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Background: Human growth hormone (GH) is widely used as an antiaging therapy, although its use for this purpose has not been approved by the U.S. Food and Drug Administration and its distribution as an antiaging agent is illegal in the United States. Purpose: To evaluate the safety and efficacy of GH therapy in the healthy elderly. Data Sources: The authors searched MEDLINE and EMBASE databases for English-language studies published through 21 November 2005 by using such terms as growth hormone ...
243 CitationsSource
#1Barbara G. Tabachnick (CSUN: California State University, Northridge)H-Index: 22
#2Linda S. Fidell (CSUN: California State University, Northridge)H-Index: 11
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#1Jeremy D. Walston (University of Pittsburgh)H-Index: 62
#2Evan C. Hadley (University of Pittsburgh)H-Index: 25
Last. Linda P. Fried (University of Pittsburgh)H-Index: 120
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Evolving definitions of frailty, and improved understanding of molecular and physiological declines in multiple systems that may increase vulnerability in frail, older adults has encouraged investigators from many disciplines to contribute to this emerging field of research. This article reports on the results of the 2004 American Geriatrics Society/National Institute on Aging conference on a Research Agenda on Frailty in Older Adults, which brought together a diverse group of clinical and basic...
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#1Analiza M. SilvaH-Index: 29
#2Jingsong WangH-Index: 67
Last. Stanley HeshkaH-Index: 40
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Aging is associated with the onset of chronic diseases that lead to pathological expansion of the extracellular water (ECW) compartment. Healthy aging, in the absence of disease, is also reportedly accompanied by a relative expansion of the ECW compartment, although the studies on which this observation is based are few in number, applied different ECW measurement methods, included small ethnically homogeneous subject samples, and failed to adjust ECW for non-age-related influencing factors. The...
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#2James T. Patrie (UVA: University of Virginia)H-Index: 41
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#1Caryl Nowson (Deakin University)H-Index: 47
#2Stella L. O’Connell (Deakin University)H-Index: 7
Declines in skeletal muscle mass and strength are major contributors to increased mortality, morbidity and reduced quality of life in older people. Recommended Dietary Allowances/Intakes have failed to adequately consider the protein requirements of the elderly with respect to function. The aim of this paper was to review definitions of optimal protein status and the evidence base for optimal dietary protein. Current recommended protein intakes for older people do not account for the compensator...
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#1Mateu Serra-Prat (ISCIII: Carlos III Health Institute)H-Index: 22
#2M. PapiolH-Index: 5
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Objective The aim of this study was to investigate the relationship between plasma ghrelin levels and sarcopenia in elderly people.
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#1Garland A. Campbell (UVA: University of Virginia)H-Index: 2
#2Warren K. Bolton (UVA: University of Virginia)H-Index: 12
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