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Effects of an Oral Ghrelin Mimetic on Body Composition and Clinical Outcomes in Healthy Older Adults

Published on Jan 1, 2015
Ralf Nass18
Estimated H-index: 18
,
Suzan S. Pezzoli21
Estimated H-index: 21
+ 7 AuthorsMichael O. Thorner66
Estimated H-index: 66
Abstract
The present invention provides synthetic compounds, antibodies that recognize and bind to these compounds, polynucleotides that encode these compounds, and immune effector cells raised in response to presentation of these epitopes. The invention further provides methods for inducing an immune response and administering immunotherapy to a subject by delivering the compositions of the invention.
  • References (46)
  • Citations (6)
References46
Newest
Published on May 1, 2012in European Journal of Endocrinology5.11
M. Elbornsson2
Estimated H-index: 2
(Sahlgrenska University Hospital),
G. Götherström6
Estimated H-index: 6
(Sahlgrenska University Hospital)
+ 3 AuthorsJohan Svensson31
Estimated H-index: 31
There are few studies that have determined the effects of long-term GH replacement on bone mineral density (BMD) in GH-deficient (GHD) adults. In this study, the effects of 10 years of GH replacement on BMD were assessed in 87 GHD adults using dual energy X-ray absorptiometry (DEXA). The results show that GH replacement induced a sustained increase in BMD at all the skeletal sites measured. Introduction: Little is known of the effect of more than 5 years of GH replacement therapy on bone metabol...
Francesco Fantin24
Estimated H-index: 24
,
Vincenzo Di Francesco23
Estimated H-index: 23
+ 7 AuthorsMauro Zamboni47
Estimated H-index: 47
(University of Verona)
Background. Few studies have evaluated prospectively age-related body composition changes and their relationships with worsening disability in the elderly population. Methods. Ninety-seven women and 62 men aged 71.4 ± 2.2 and 71.6 ± 2.2 years, respectively, at baseline underwent dual-energy x-ray absorptiometry determinations at baseline and at 2- and 5.5-year follow-up intervals to measure total body and leg fat (FM) and total, appendicular, and leg fat-free mass (FFM). Height, weight, body mas...
Published on Dec 1, 2007in Current Pharmaceutical Design2.41
John E. Morley Mb BCh131
Estimated H-index: 131
There is now a large body of evidence that weight loss in older persons not only increases mortality, but also increases the incidence of hip fracture, functional deterioration and institutionalization. Weight loss is a central component of frailty. There is evidence that it is not only muscle, but also fat loss that leads to these deleterious effects. The reasons why fat loss can be harmful in older persons are reviewed. There are four major causes of weight loss in older persons viz. anorexia,...
Published on Aug 1, 2007in Clinical Nutrition6.40
David R. Thomas35
Estimated H-index: 35
(SLU: Saint Louis University)
Summary A loss of body weight or skeletal muscle mass is common in older persons and is a harbinger of poor outcome. Involuntary weight loss can be categorized into three primary etiologies of starvation, sarcopenia, and cachexia. Starvation results in a loss of body fat and non-fat mass due to inadequate intake of protein and energy. Sarcopenia is associated with a reduction in muscle mass and strength occurring with normal aging, associated with a reduction in motor unit number and atrophy of ...
Published on Jun 1, 2007in Diabetes7.20
Juan-Pablo del Rincon3
Estimated H-index: 3
,
Keiji Iida23
Estimated H-index: 23
+ 7 AuthorsMichael O. Thorner66
Estimated H-index: 66
Phosphoinositide (PI) 3-kinase is involved in insulin-mediated effects on glucose uptake, lipid deposition, and adiponectin secretion from adipocytes. Genetic disruption of the p85α regulatory subunit of PI 3-kinase increases insulin sensitivity, whereas elevated p85α levels are associated with insulin resistance through PI 3-kinase–dependent and –independent mechanisms. Adipose tissue plays a critical role in the antagonistic effects of growth hormone (GH) on insulin actions on carbohydrate and...
Published on Jan 16, 2007in Annals of Internal Medicine19.32
Hau Liu12
Estimated H-index: 12
(Stanford University),
Dena M. Bravata31
Estimated H-index: 31
(Stanford University)
+ 4 AuthorsAndrew R. Hoffman70
Estimated H-index: 70
(Stanford University)
Background: Human growth hormone (GH) is widely used as an antiaging therapy, although its use for this purpose has not been approved by the U.S. Food and Drug Administration and its distribution as an antiaging agent is illegal in the United States. Purpose: To evaluate the safety and efficacy of GH therapy in the healthy elderly. Data Sources: The authors searched MEDLINE and EMBASE databases for English-language studies published through 21 November 2005 by using such terms as growth hormone ...
Published on Jan 1, 2007
Barbara G. Tabachnick24
Estimated H-index: 24
(CSUN: California State University, Northridge),
Linda S. Fidell11
Estimated H-index: 11
(CSUN: California State University, Northridge)
Published on Jun 1, 2006in Journal of the American Geriatrics Society4.11
Jeremy D. Walston60
Estimated H-index: 60
(University of Pittsburgh),
Evan Hadley2
Estimated H-index: 2
(University of Pittsburgh)
+ 6 AuthorsLinda P. Fried117
Estimated H-index: 117
(University of Pittsburgh)
Evolving definitions of frailty, and improved understanding of molecular and physiological declines in multiple systems that may increase vulnerability in frail, older adults has encouraged investigators from many disciplines to contribute to this emerging field of research. This article reports on the results of the 2004 American Geriatrics Society/National Institute on Aging conference on a Research Agenda on Frailty in Older Adults, which brought together a diverse group of clinical and basic...
Published on Nov 1, 2005in Mental Health Practice
Paul Rogers9
Estimated H-index: 9
Published on Jul 1, 2005in Journal of Applied Physiology3.14
Analiza M. Silva28
Estimated H-index: 28
,
Jingsong Wang75
Estimated H-index: 75
+ 4 AuthorsStanley Heshka50
Estimated H-index: 50
Aging is associated with the onset of chronic diseases that lead to pathological expansion of the extracellular water (ECW) compartment. Healthy aging, in the absence of disease, is also reportedly accompanied by a relative expansion of the ECW compartment, although the studies on which this observation is based are few in number, applied different ECW measurement methods, included small ethnically homogeneous subject samples, and failed to adjust ECW for non-age-related influencing factors. The...
Cited By6
Newest
Published on Mar 1, 2018in Nephrology Dialysis Transplantation4.20
Garland Adam Campbell2
Estimated H-index: 2
(UVA: University of Virginia),
James T. Patrie39
Estimated H-index: 39
(UVA: University of Virginia)
+ 2 AuthorsWarren K. Bolton13
Estimated H-index: 13
(UVA: University of Virginia)
Published on Aug 14, 2015in Nutrients4.17
Caryl Nowson46
Estimated H-index: 46
(Deakin University),
Stella O'Connell4
Estimated H-index: 4
(Deakin University)
Declines in skeletal muscle mass and strength are major contributors to increased mortality, morbidity and reduced quality of life in older people. Recommended Dietary Allowances/Intakes have failed to adequately consider the protein requirements of the elderly with respect to function. The aim of this paper was to review definitions of optimal protein status and the evidence base for optimal dietary protein. Current recommended protein intakes for older people do not account for the compensator...
Published on Jun 1, 2015in Journal of Nutrition Health & Aging2.66
Mateu Serra-Prat21
Estimated H-index: 21
(ISCIII: Instituto de Salud Carlos III),
M. Papiol5
Estimated H-index: 5
+ 2 AuthorsMateu Cabré11
Estimated H-index: 11
Objective The aim of this study was to investigate the relationship between plasma ghrelin levels and sarcopenia in elderly people.
Published on Nov 1, 2014in Seminars in Dialysis2.06
Garland Adam Campbell2
Estimated H-index: 2
(UVA: University of Virginia),
Warren K. Bolton13
Estimated H-index: 13
(UVA: University of Virginia)
Published on Jun 1, 2013in Endocrinology and Metabolism Clinics of North America3.31
John E. Morley Mb BCh131
Estimated H-index: 131
(SLU: Saint Louis University),
Theodore K. Malmstrom31
Estimated H-index: 31
(SLU: Saint Louis University)
Frailty is now a definable clinical syndrome with a simple screening test. Age-related changes in hormones play a major role in the development of frailty by reducing muscle mass and strength (sarcopenia). Selective Androgen Receptor Molecules and ghrelin agonists are being developed to treat sarcopenia. The role of Activin Type IIB soluble receptors and Follistatin-like 3 mimetics is less certain because of side effects. Exercise (resistance and aerobic), vitamin D and protein supplementation, ...
Published on Sep 1, 2011in Physiology & Behavior2.63
Fabienne Langlois5
Estimated H-index: 5
(Centre Hospitalier Universitaire de Sherbrooke),
Marie-France Langlois20
Estimated H-index: 20
(Centre Hospitalier Universitaire de Sherbrooke)
+ 3 AuthorsMarie-France Hivert36
Estimated H-index: 36
(Centre Hospitalier Universitaire de Sherbrooke)
Abstract Weight gain and appetite regulation are complex interplays between internal and external cues. Our aim was to investigate the association of eating behaviors with ghrelin taking into account lifestyle. We conducted a cross-sectional analysis in a sample of first-year university students at the Universite de Sherbrooke. We collected medical history, anthropometric measurements, vital signs, fitness index, and fasting blood samples. Questionnaires included a lifestyle questionnaire and th...
Published on Apr 1, 2009in The Journal of Clinical Endocrinology and Metabolism5.61
Heidi K. White18
Estimated H-index: 18
(Duke University),
Charles D. Petrie6
Estimated H-index: 6
(Pfizer)
+ 10 AuthorsMark P. Ettinger18
Estimated H-index: 18
Context: GH secretion declines with age, possibly contributing to reduced muscle mass, strength, and function. GH secretagogues (GHS) may increase muscle mass and physical performance. Objectives/Design: We conducted a randomized, double-masked, placebo-controlled, multicenter study to investigate the hormonal, body composition, and physical performance effects and the safety of the orally active GHS capromorelin in older adults with mild functional limitation. Intervention/Participants: A total...
View next paperEffects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial.