A transcriptional co‐repressor regulatory circuit controlling the heat‐shock response of Mycobacterium tuberculosis

Summary The co‐ordinated regulation of heat shock proteins is critically important for the stress response of M . tuberculosis , failure of which results in enhanced immune recognition of the tubercle bacilli with reduced survival during chronic infections. In this study, we show that PhoP regulates the transcription of α‐crystallin 2 ( acr2 ), expression of which increases more than any other gene of M . tuberculosis during heat‐shock or...