HDLassociated PAF‐AH reduces endothelial adhesiveness in apoE−/−mice
Abstract
Macrophage infiltration into the subendothelial space at lesion prone sites is the primary event in atherogenesis. Inhibition of macrophage homing might therefore prevent atherosclerosis. Since HDL levels are inversely correlated with cardiovascular risk, their effect on macrophage homing was assessed in apoE-deficient (apoE-/-) mice. Overexpression of human apolipoprotein AI in apoE-/- mice increased HDL levels 3-fold and reduced macrophage...
Paper Details
Title
HDLassociated PAF‐AH reduces endothelial adhesiveness in apoE−/−mice
Published Date
Oct 1, 2000
Journal
Volume
14
Issue
13
Pages
2032 - 2039
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