Original paper

New Features of the Ribosome and Ribosomal Inhibitors: Non-Enzymatic Recycling, Misreading and Back-Translocation

Volume: 380, Issue: 1, Pages: 193 - 205
Published: Jun 1, 2008
Abstract
We describe the optimization of a poly(Phe) synthesis system, the conditions of which have been applied for efficient translation of heteropolymeric mRNAs. Here we identify two parameters that are essential to obtain translation at efficiency and accuracy levels equivalent to those in vivo, viz., the fine-tuning of the energy-rich components with an acetyl-phosphate substrate for energy regeneration, as well as the ionic conditions. Applying...
Paper Details
Title
New Features of the Ribosome and Ribosomal Inhibitors: Non-Enzymatic Recycling, Misreading and Back-Translocation
Published Date
Jun 1, 2008
Volume
380
Issue
1
Pages
193 - 205
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