γδ T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice

γδ T cells are resident in AT and increase during diet-induced obesity. Their possible contribution to the inflammatory response that accompanies diet-induced obesity was investigated in mice after a 5 to 10 week milk HFD. The HFD resulted in significant increases in CD44hi, CD62Llo, and TNF-α+ γδ T cells in eAT of WT mice. Mice deficient in all γδ T cells (TCRδ−/−) or only Vγ4 and Vγ6 subsets (Vγ4/6−/−) were compared with WT mice with regard to...