Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins

Volume: 189, Issue: 2, Pages: 289 - 300
Published: Jan 18, 1999
Abstract
A key feature of B and T lymphocyte development is the generation of antigen receptors through the rearrangement and assembly of the germline variable (V), diversity (D), and joining (J) gene segments. However, the mechanisms responsible for regulating developmentally ordered gene rearrangements are largely unknown. Here we show that the E2A gene products are essential for the proper coordinated temporal regulation of V(D)J rearrangements within...
Paper Details
Title
Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins
Published Date
Jan 18, 1999
Volume
189
Issue
2
Pages
289 - 300
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