Adipose Modulation of High-Density Lipoprotein Cholesterol Implications for Obesity, High-Density Lipoprotein Metabolism, and Cardiovascular Disease

Published on Oct 11, 2011in Circulation23.05
· DOI :10.1161/CIRCULATIONAHA.111.058453
Fiona C. McGillicuddy19
Estimated H-index: 19
Muredach P. Reilly92
Estimated H-index: 92
Daniel J. Rader137
Estimated H-index: 137
High-density lipoprotein-cholesterol (HDL-C) levels inversely correlate with atherosclerotic cardiovascular disease (CVD).1 HDL plays a key role in reverse cholesterol transport by promoting cholesterol efflux from peripheral cells, including cholesterol-laden macrophages, and delivering acquired cholesterol to liver for excretion, a process that is believed to be atheroprotective.2 However, whether low HDL-C is merely a bystander or is causal in CVD remains controversial.3 Genetic factors that influence HDL-C levels are not consistently associated with altered CVD risk, and failure of the cholesterol ester transfer protein inhibitor torcetrapib and, more recently, niacin to reduce cardiovascular events, despite their HDL-raising effects, has raised doubts about the therapeutic potential of raising HDL.4,5 We recently demonstrated that measurement of HDL efflux capacity is a stronger predictor of CVD than plasma HDL-C levels,6 strengthening the argument that measures of HDL functionality may be more useful than HDL-C levels as predictors of risk and better targets of novel therapies. In any case, regulation of HDL metabolism and function and their relationship to atherosclerosis remains incompletely understood.
  • References (19)
  • Citations (22)
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