Original paper
Hormonal Control of C. elegans Dauer Formation and Life Span by a Rieske-like Oxygenase
Abstract
C. elegans diapause, gonadal outgrowth, and life span are regulated by a lipophilic hormone, which serves as a ligand to the nuclear hormone receptor DAF-12. A key step in hormone production is catalyzed by the CYP450 DAF-9, but the extent of the biosynthetic pathway is unknown. Here, we identify a conserved Rieske-like oxygenase, DAF-36, as a component in hormone metabolism. Mutants display larval developmental and adult aging phenotypes, as...
Paper Details
Title
Hormonal Control of C. elegans Dauer Formation and Life Span by a Rieske-like Oxygenase
Published Date
Apr 1, 2006
Journal
Volume
10
Issue
4
Pages
473 - 482
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Notes
History