Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes
Volume: 302, Issue: 3, Pages: C597 - C604
Published: Feb 1, 2012
Abstract
Oxidative stress contributes to diabetic cardiomyopathy. This study explored the role of the NADPH oxidase Nox4 as a source of reactive oxygen species (ROS) involved in the development of diabetic cardiomyopathy. Phosphorothioated antisense (AS) or sense (S) oligonucleotides for Nox4 were administered for 2 wk to rats made diabetic by streptozotocin. NADPH oxidase activity, ROS generation, and the expression of Nox4, but Nox1 or Nox2, were...
Paper Details
Title
Nox4-derived reactive oxygen species mediate cardiomyocyte injury in early type 1 diabetes
Published Date
Feb 1, 2012
Volume
302
Issue
3
Pages
C597 - C604
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