Microvascular Contributions to Insulin Resistance

The notion that type 2 diabetes and insulin resistance are associated with many macro- and microvascular defects (1,2) is unquestionable, but whether vascular defects precede and contribute to insulin resistance is less certain and has been a controversial topic. The most compelling evidence for a vascular involvement in insulin resistance has been in skeletal muscle (3), but recent research has also implicated its involvement in adipose tissue...