Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Abstract
Epigenetic mechanisms have been proposed to play crucial roles in mammalian development, but their precise functions are only partially understood. To investigate epigenetic regulation of embryonic development, we differentiated human embryonic stem cells into mesendoderm, neural progenitor cells, trophoblast-like cells, and mesenchymal stem cells and systematically characterized DNA methylation, chromatin modifications, and the transcriptome in...
Paper Details
Title
Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Published Date
May 23, 2013
Journal
Volume
153
Issue
5
Pages
1134 - 1148
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