Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Abstract
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterations in mtDNA from 1675 tumors. We identified 1907 somatic substitutions, which exhibited dramatic replicative strand bias, predominantly C > T...
Paper Details
Title
Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer
Published Date
Oct 1, 2014
Journal
Volume
3
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