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References39
Newest
Published on Sep 1, 2013in Medical Clinics of North America 2.58
Magnus Löndahl18
Estimated H-index: 18
(Lund University)
Hyperbaric oxygen therapy (HBO) is a short-term, high-dose oxygen inhalation and diffusion therapy, delivered systemically through airways and blood under high pressure using hyperbaric chambers. HBO stimulates angiogenesis, reduces edema, augments granulation tissue formation by enhancing fibroblasts, and improves leukocyte function by elevating the partial pressure of oxygen in tissue. The number of clinical trials evaluating the effect of HBO on the healing of diabetic foot ulcers is increasi...
21 Citations Source Cite
Shuhong Feng3
Estimated H-index: 3
(Tianjin Medical University),
Yuejie Chu3
Estimated H-index: 3
(Tianjin Medical University)
+ 3 AuthorsXuemei Li2
Estimated H-index: 2
(Tianjin Medical University)
The objective was to study risk factors and gene type of DF patients infected with MRSA. A total of 429 DF patients were recruited. The patients with S aureus infections were divided into MRSA and MSSA groups. MRSA were genotyped by SCCmec. pvl and lukE-lukD were detected. A total of 559 pathogens were isolated from them, with G+ bacteria firstly(59.0%), followed G- bacilli (37.7%) and true fungi (3.3%). The 3 most frequently isolated pathogens were S aureus (35.2%), S epidermidis (12.3%), and P...
10 Citations Source Cite
Magnus Löndahl18
Estimated H-index: 18
(Lund University)
Hyperbaric oxygen therapy (HBOT) has been suggested to improve healing of hard-to-heal diabetic foot ulcers. Although the wide use of HBOT as a treatment for diabetic foot ulcers has been founded on weak scientific ground, 2 well-designed randomized, double-blind, placebo-controlled studies have in recent years put HBOT on firmer ground as treatment for diabetic patients with chronic foot ulcers. The recognition of inclusion criteria in these studies may help identify a select group of diabetic ...
11 Citations Source Cite
Efstratios Georgakarakos16
Estimated H-index: 16
(Democritus University of Thrace),
Dimitris Charalampidis1
Estimated H-index: 1
(Democritus University of Thrace)
+ 3 AuthorsNikolaos Papanas32
Estimated H-index: 32
(Democritus University of Thrace)
Negative pressure wound therapy has been increasingly used either as a primary or as an adjunctive therapeutic measure to treat a variety of recalcitrant wounds during the past years. It is thought to act by creating a local environment that promotes cell proliferation, angiogenesis, and granulation tissue formation, leading to accelerated wound healing to the point of spontaneous closure or reducing the wound size to facilitate significantly further surgical reconstruction. This case series pre...
8 Citations Source Cite
Maria Demetriou6
Estimated H-index: 6
(Democritus University of Thrace),
Nikolaos Papanas32
Estimated H-index: 32
(Democritus University of Thrace)
+ 3 AuthorsEfstratios Maltezos32
Estimated H-index: 32
(Democritus University of Thrace)
We evaluated the diagnostic performance of swabs versus tissue cultures in 28 diabetic patients with neuropathic (group A) and 22 diabetic patients with neuroischemic foot ulcer (group B) and the differences in bacterial isolates between the 2 groups. In group A, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of swab cultures for the diagnosis of infection were 100%, 40%, 88.5%, and 100%, respectively. In group B, the corresponding values were 100%...
16 Citations Source Cite
Marios Michail2
Estimated H-index: 2
(Athens State University),
Edward B. Jude37
Estimated H-index: 37
(University of Manchester)
+ 5 AuthorsNicholas Tentolouris23
Estimated H-index: 23
(Athens State University)
Serum inflammatory markers, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), white blood cells (WBC), and procalcitonin (PCT), have been used for the diagnosis of foot infections in patients with diabetes. However, little is known about their changes during treatment of patients with foot infections. The aim of this prospective study was to examine the performance of serum inflammatory markers for the diagnosis and follow-up of patients with osteomyelitis. A total of 61 patients (...
45 Citations Source Cite
Markus Loeffler77
Estimated H-index: 77
(University of Tübingen),
Heiko Schuster13
Estimated H-index: 13
(University of Tübingen)
+ 1 AuthorsStefan Beckert17
Estimated H-index: 17
(University of Tübingen)
Valid and reproducible sampling techniques as well as processing protocols are required for the assessment of biomarkers and mediators contained in wound exudate. Moreover, the ideal technique should be easy to use even in daily clinical routine. This is challenging since wound fluid represents an inhomogeneous mixture of different exogenous and endogenous sources. Analyzing wound fluid, however, may facilitate clinical decision making. Many techniques for obtaining wound fluid have been describ...
8 Citations Source Cite
Javier Aragón-Sánchez17
Estimated H-index: 17
,
José Luis Lázaro-Martínez16
Estimated H-index: 16
(Complutense University of Madrid)
+ 3 AuthorsMaria J. Hernández-Herrero9
Estimated H-index: 9
Revision surgery (RS) is frequently needed to control diabetic foot infections. It is the aim of this retrospective observational study to analyze the variables associated with undergoing RS and the variables associated with undergoing a major amputation when RS was required. We conducted a retrospective study of patients with diabetes treated in our department during 10 years (January 1, 2000 to January 1, 2010) who had foot infections identifying those who required RS. In all, 167 out of 417 p...
8 Citations Source Cite
Vijay Viswanathan4
Estimated H-index: 4
,
V Narayan Rao2
Estimated H-index: 2
The burden of diabetic foot complications, in terms of both physical and socioeconomical constraints, poses a heavy challenge both to the patient and the physician, especially in developing countries, where the number of people living with diabetes is increasing at an alarming rate compared with the developed world. In developing countries like India, there are specific causes and risk factors that increase the burden of diabetic foot infections (DFIs), for example, sociocultural risk factors su...
9 Citations Source Cite
Published on Jun 1, 2013in Current Pharmaceutical Design 2.76
Michael Edmonds43
Estimated H-index: 43
(King's College London)
9 Citations Source Cite
Cited By17
Newest
Published on Jun 13, 2019in Expert Opinion on Pharmacotherapy 3.48
Ioanna Eleftheriadou6
Estimated H-index: 6
(National and Kapodistrian University of Athens),
Anastasios Tentolouris3
Estimated H-index: 3
(National and Kapodistrian University of Athens)
+ 1 AuthorsNikolaos Papanas32
Estimated H-index: 32
(Democritus University of Thrace)
Source Cite
Nikolaos Papanas32
Estimated H-index: 32
(Democritus University of Thrace),
Massimo Papi1
Estimated H-index: 1
(National Institutes of Health),
Kittipan Rerkasem19
Estimated H-index: 19
(Chiang Mai University)
Source Cite
Prashanth Vas3
Estimated H-index: 3
(University of Cambridge),
Periklis Panagopoulos3
Estimated H-index: 3
(Democritus University of Thrace),
Nikolaos Papanas32
Estimated H-index: 32
(Democritus University of Thrace)
1 Citations Source Cite
Alfred Gatt8
Estimated H-index: 8
(University of Malta),
Owen Falzon6
Estimated H-index: 6
(University of Malta)
+ 9 AuthorsCassandra Sturgeon2
Estimated H-index: 2
(University of Malta)
This study aimed to determine whether thermal imaging can detect temperature differences between healthy feet, nonulcerated neuroischemic feet, and neuroischemic feet with toe ulcers in patients with type 2 diabetes mellitus (T2DM). Participants were prospectively divided into 3 groups: T2DM without foot problems; a healthy, nonulcerated neuroischemic group, and an ulcerated neuroischemic group. Thermal images of the feet were obtained with automated segmentation of regions of interest. Thermogr...
1 Citations Source Cite
Maria Demetriou6
Estimated H-index: 6
,
Nikolaos Papanas32
Estimated H-index: 32
+ 2 AuthorsEfstratios Maltezos32
Estimated H-index: 32
Diabetic foot infections are a common and serious problem for all health systems worldwide. The aim of this study was to examine the resistance to antibiotics of microorganisms isolated from infected soft tissues of diabetic foot ulcers, using tissue cultures. We included 113 consecutive patients (70 men, 43 women) with a mean age of 66.4 ± 11.2 years and a mean diabetes duration of 14.4 ± 7.6 years presenting with diabetic foot soft tissue infections. Generally, no high antibiotic resistance wa...
2 Citations Source Cite
Prashant R. J. Vas1
Estimated H-index: 1
,
Michael Edmonds43
Estimated H-index: 43
,
Nikolaos Papanas32
Estimated H-index: 32
Diabetic foot ulcers remain difficult to heal and nutritional supplementation may be an important complementary therapeutic measure. However, we need to clarify many issues before such supplementation is more widely used. Indeed, improvements are needed in the following areas: evaluation of nutritional inadequacy, completion of randomized controlled trials, understanding of patient and ulcer characteristics that favor response to nutritional supplementation, optimal duration of supplementation t...
1 Citations Source Cite
Published on Jan 1, 2017in Experimental Diabetes Research
I. Migdalis1
Estimated H-index: 1
,
L. Czupryniak1
Estimated H-index: 1
+ 3 AuthorsP. Valensi43
Estimated H-index: 43
1 Citations Source Cite
Published on Sep 1, 2016in Wound Repair and Regeneration 2.95
Carlos A. Hinojosa8
Estimated H-index: 8
,
Estefanía Boyer-Duck1
Estimated H-index: 1
+ 4 AuthorsRene Lizola2
Estimated H-index: 2
Infections in feet of patients with diabetes mellitus is common, complex and costly. The aim of this study to investigate the isolated microorganisms in infected diabetic foot ulcers, and the impact of these infectious agents in limb loss in a tertiary medical center in Mexico City. We conducted a retrospective review in diabetic patients with infected foot ulcers from 1997 to 2014. Diabetic foot was defined according to the World Health Organization (WHO), the bacteriology of wound cultures and...
3 Citations Source Cite
Nikolaos Papanas32
Estimated H-index: 32
(Democritus University of Thrace),
Costas Demetzos32
Estimated H-index: 32
(National and Kapodistrian University of Athens)
+ 2 AuthorsNicholas Tentolouris8
Estimated H-index: 8
(National and Kapodistrian University of Athens)
A novel heparan sulfate glycosaminoglycan mimetic product for local application to promote wound healing (CACIPLIQ) has recently become available. It is a biophysical therapeutic product comprising a polysaccharide as an innovative biomaterial to accomplish mechanical tissue engineering and skin regeneration in the site of ulceration. We present a series of 12 patients with type 2 diabetes (4 men and 8 women; age 53-87 years; diabetes duration 8-25 years) having chronic resistance to therapy for...
8 Citations Source Cite