Original paper

BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery

Volume: 209, Issue: 4, Pages: 563 - 577
Published: May 25, 2015
Abstract
Hermansky–Pudlak syndrome (HPS) is a group of disorders characterized by the malformation of lysosome-related organelles, such as pigment cell melanosomes. Three of nine characterized HPS subtypes result from mutations in subunits of BLOC-2, a protein complex with no known molecular function. In this paper, we exploit melanocytes from mouse HPS models to place BLOC-2 within a cargo transport pathway from recycling endosomal domains to maturing...
Paper Details
Title
BLOC-2 targets recycling endosomal tubules to melanosomes for cargo delivery
Published Date
May 25, 2015
Volume
209
Issue
4
Pages
563 - 577
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