Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal
Abstract
Prolonged glucosamine (GlcN) infusion increases the skeletal muscle hexosamine concentration and induces peripheral insulin resistance in conscious rats. IGF-1 and insulin share common steps in signal transduction, and the action of IGF-1 on carbohydrate metabolism is preserved in certain insulin-resistant states. In our study, we attempted to delineate whether increased GlcN availability also impairs the effects of IGF-1 on glucose uptake (Rd),...
Paper Details
Title
Increased Hexosamine Availability Similarly Impairs the Action of Insulin and IGF-1 on Glucose Disposal
Published Date
Dec 1, 1996
Journal
Volume
45
Issue
12
Pages
1734 - 1743
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