Regional Adiposity and Insulin Resistance

It is well recognized that persons with generalized obesity suffer from a high risk of insulin resistance and its metabolic complications, such as type 2 diabetes mellitus, hypertriglyceridemia, low levels of high density lipoprotein cholesterol, hypertension, hepatic steatosis, hyperuricemia, and atherosclerotic vascular disease (1–3). However, whether accumulation of adipose tissue in a particular anatomical compartment (regional adiposity)...