Cell type–specific gene expression differences in complex tissues
Abstract
We describe cell type-specific significance analysis of microarrays (csSAM) for analyzing differential gene expression for each cell type in a biological sample from microarray data and relative cell-type frequencies. First, we validated csSAM with predesigned mixtures and then applied it to whole-blood gene expression datasets from stable post-transplant kidney transplant recipients and those experiencing acute transplant rejection, which...
Paper Details
Title
Cell type–specific gene expression differences in complex tissues
Published Date
Apr 1, 2010
Journal
Volume
7
Issue
4
Pages
287 - 289
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