Label-Free Analysis of Thrombin or Hg2+Ions by Nucleic Acid-Functionalized Graphene Oxide Matrices Assembled on Field-Effect Transistors
Abstract
Graphene oxide (GO) is deposited onto the Al2O3 gates of field-effect transistor devices to yield a functional matrix for the sensing of thrombin or Hg2+ ions. The deposition of an aptamer subunit against thrombin or a tailored nucleic acid with appropriate T mismatches on the GO, yield active surfaces for the analysis of thrombin or Hg2+ ions. The desorption of the aptamer-subunit from GO, through the formation of the aptamer-thrombin complex,...
Paper Details
Title
Label-Free Analysis of Thrombin or Hg2+Ions by Nucleic Acid-Functionalized Graphene Oxide Matrices Assembled on Field-Effect Transistors
Published Date
Dec 23, 2012
Journal
Volume
25
Issue
4
Pages
851 - 856
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